MilliporeSigma

1.00681

SAFC

Succinic acid

crystalline, EMPROVE® ESSENTIAL, ChP, NF, JPE, ACS

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Synonym(s):
Butanedioic acid
Linear Formula:
HOOCCH2CH2COOH
CAS Number:
Molecular Weight:
118.09
Beilstein:
1754069
MDL number:
EC Index Number:
203-740-4

grade

ACS reagent

Quality Level

Agency

ChP
JPE
NF

product line

EMPROVE® ESSENTIAL

Assay

99.0-100.5% (HPLC)

form

crystalline
solid

autoignition temp.

470 °C

technique(s)

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

bp

235 °C (lit.)
235 °C/1013 hPa

mp

184-186 °C (lit.)

transition temp

flash point 206 °C

solubility

58 g/L

density

1.56 g/cm3 at 20 °C

anion traces

chloride (Cl-): ≤0.001%
phosphate (PO43-): ≤0.001%
sulfate (SO42-): ≤0.003%

cation traces

As: ≤0.0002%
Fe: ≤5 ppm
heavy metals (as Pb): ≤0.0020%
heavy metals (as Pb): ≤5 ppm

application(s)

liquid formulation
pharma/biopharma processes
pharmaceutical
solid formulation

storage temp.

2-30°C

SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

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1 of 4

This Item
1.006628.170588.17073
Succinic acid crystalline, EMPROVE® ESSENTIAL, ChP, NF, JPE, ACS

SAFC

1.00681

Succinic acid

Sorbic acid EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, NF, FCC, E 200

SAFC

1.00662

Sorbic acid

Maleic acid EMPROVE® ESSENTIAL, Ph. Eur., NF

SAFC

8.17058

Maleic acid

Fumaric acid EMPROVE® ESSENTIAL, NF, JPE

SAFC

8.17073

Fumaric acid

agency

ChP, JPE, NF

agency

BP, ChP, NF, Ph. Eur.

agency

NF, Ph. Eur.

agency

JPE, NF

assay

99.0-100.5% (HPLC)

assay

99.0-101.0% substance (anhydrous) basis (acidimetric)

assay

99.0-101.0% substance (anhydrous) basis

assay

-

form

crystalline, solid

form

solid

form

solid

form

solid

bp

235 °C (lit.), 235 °C/1013 hPa

bp

160-260 °C/1013 hPa (decomposition)

bp

-

bp

290 °C/1013 hPa (sublimed)

mp

184-186 °C (lit.)

mp

120-150 °C

mp

130-135 °C (lit.)

mp

287 °C

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Succinic acid is a commonly used ingredient in pharmaceutical applications. In such applications it has been used primarily for solid oral dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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