400046
Hydroxyurea
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.
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Synonym(s):
Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I
Empirical Formula (Hill Notation):
CH4N2O2
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key
VSNHCAURESNICA-UHFFFAOYSA-N
General description
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Other Notes
Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 2
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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