H8627

Hydroxyurea

98%, powder

• Synonym(s): Hydroxycarbamide
• Linear Formula: NH₂CONHOH
• CAS Number: 127-07-1
• Molecular Weight: 76.05
• Beilstein: 1741548
• EC Number: 204-821-7
• MDL number: MFCD00007943
• PubChem Substance ID: 24278474
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: 98%
• form: powder
• color: white
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: VSNHCAURESNICA-UHFFFAOYSA-N
• Gene Information: human ... CA1(759) , CA2(760) , CYP1A2(1544) , RRM1(6240) , RRM2(6241) , RRM2B(50484)

Description

Application

Hydroxyurea has been used:

• for cell cycle synchronization in MCF-7 human breast carcinoma cells, Schizosaccharomyces pombe, primary root of seedling
• as a drug for treating the parasite Leishmania mexicana in cell viability and cell cycle assay
• as an inhibitor in the cell adhesion and motility assay in Caki control and CD9 knockdown cells

Biochem/physiol Actions

Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H340 - H361
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Muta. 1B - Repr. 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves