MT1-MMP, Catalytic Domain, Human, Recombinant, E. coli

Name: MT1-MMP, Catalytic Domain, Human, Recombinant, <i>E. coli</i>
Brand: MM

Synonym(s):

MMP-14 Catalytic Domain

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About This Item

NACRES:

NA.77

UNSPSC Code:

12352202

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Key Documents

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assay

≥90% (SDS-PAGE)

form

liquid

specific activity

≥140 mU/mg protein

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

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Show Differences

1 of 4

This Item	444217	444270	444248
Sigma-Aldrich 475935 MT1-MMP, Catalytic Domain, Human, Recombinant, E. coli	Sigma-Aldrich 444217 MMP-3, Catalytic Domain, Human, Recombinant, E. coli	Sigma-Aldrich 444270 MMP-7, Active, Human, Recombinant, E. coli	Sigma-Aldrich 444248 MMP-13, Proenzyme, His•Tag^®, Human, Recombinant, S. frugiperda
specific activity ≥140 mU/mg protein	specific activity ≥1250 mU/mg protein	specific activity ≥3000 units/mg protein	specific activity ≥50 mU/mg protein
assay ≥90% (SDS-PAGE)	assay ≥90% (SDS-PAGE)	assay -	assay ≥90% (SDS-PAGE)
form liquid	form liquid	form liquid	form liquid
storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles
storage temp. −70°C	storage temp. −70°C	storage temp. −70°C	storage temp. −70°C
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice

Disclaimer

Toxicity: Standard Handling (A)

General description

Note: 1 mU = 1 milliunit.

Recombinant, human pro-MT1-MMP expressed in E. coli and activated to yield the active catalytic domain (amino acids 89-265). The catalytic domain is comprised of amino acid residues Tyr⁸⁹ to Gly²⁶⁵ of mature human MT1-MMP. Hydrolyzes fibrillar collagens I, II, and III, as well as other extracellular matrix proteins, and activates MMP-2 and MMP-13, resulting in enhanced proteolysis of the matrix for cell migration and proliferation.

Other Notes

Amano, T., et al. 2005. Cell Res.15, 150.
Knauper, V., et al. 1996. J. Biol. Chem. 271, 17124.
Pei, D., and Weiss, S.J. 1996. J. Biol. Chem. 271, 9135.
Sato, H., et al. 1994. Nature370, 61.
Knight, C.G., et al. 1992. REBS Lett.296, 263.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 150 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, pH 7.5.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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