5.08160

DPDPE

• Synonym(s): DPDPE, δ Opioid Receptor Agonist, DPDPE
• Empirical Formula (Hill Notation): C₃₀H₃₉N₅O₇S₂
• CAS Number: 88373-73-3
• Molecular Weight: 645.79
• MDL number: MFCD00076430
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• SMILES string: S1SC([C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C1(C)C)C(=O)O)Cc3ccccc3)NC(=O)[C@@H](N)Cc2ccc(cc2)O)(C)C
• InChI: 1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
• InChI key: MCMMCRYPQBNCPH-WMIMKTLMSA-N
• assay: ≥99% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: water: 1 mg/mL
• storage temp.: −20°C
• Quality Level: 100

Description

Biochem/physiol Actions

Primary Target
δ opioid receptor

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent agonist selective for δ opioid receptor (EC₅₀ = 5.2 nM). Exhibits anti-convulsant effects in vivo in rats, also used in nociceptive studies.

Other Notes

Chen, C., 1997. J. Pharmacol. Exp. Ther.283, 1151.
Chandrakumar, S., et al., 1992. J. Med. Chem.35, 2928.
Tortella, F. 1988. Peptides.9, 1177.
Clark, A., et al., 1986. Eur. J. Pharmacol.128, 303.

Tyr-D-Pen-Gly-Phe-D-Pen (2-5 disulfide bond)

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable