681641

Wee1 Inhibitor II

The Wee1 Inhibitor II, also referenced under CAS 622855-50-9, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): Wee1 Inhibitor II, 6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
• Empirical Formula (Hill Notation): C₂₄H₁₉ClN₂O₃
• CAS Number: 622855-50-9
• Molecular Weight: 418.87
• MDL number: MFCD28138108
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Wee1 Inhibitor II, The Wee1 Inhibitor II, also referenced under CAS 622855-50-9, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• InChI key: HLSZACLAFZWCCS-UHFFFAOYSA-N
• InChI: 1S/C24H19ClN2O3/c1-2-3-10-27-18-9-8-13(28)11-16(18)20-19(27)12-15(14-6-4-5-7-17(14)25)21-22(20)24(30)26-23(21)29/h4-9,11-12,28H,2-3,10H2,1H3,(H,26,29,30)
• SMILES string: Clc1c(cccc1)c2c3c(c4c([n](c5c4cc(cc5)O)CCCC)c2)[c]([nH][c]3=O)=O
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: brown
• solubility: DMSO: 10 mg/mL; ethanol: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• Quality Level: 100

Description

Biochem/physiol Actions

Target IC₅₀: 59 nM against Wee1

Cell permeable: no

Primary Target
Wee1

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 35 µM).

Other Notes

Palmer, B.D., et al. 2006. J. Med. Chem.49, 4896.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable