A7219

L-Aspartic acid

from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

• Synonym(s): (S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid
• Linear Formula: HO₂CCH₂CH(NH₂)CO₂H
• CAS Number: 56-84-8
• Molecular Weight: 133.10
• Beilstein: 1723530
• EC Number: 200-291-6
• MDL number: MFCD00002616
• eCl@ss: 32160406
• PubChem Substance ID: 24891191
• NACRES: NA.75

Properties

• biological source: non-animal source
• Quality Level: 300
• Agency: meets EP testing specifications; meets USP testing specifications
• Assay: 98.5-101.0%
• form: powder
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• color: white to off-white
• mp: >300 °C (dec.) (lit.)
• solubility: 1 M HCl: 100 mg/mL
• SMILES string: N[C@@H](CC(O)=O)C(O)=O
• InChI: 1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
• InChI key: CKLJMWTZIZZHCS-REOHCLBHSA-N
• Gene Information: human ... CA1(759) , CA2(760) ; rat ... Grin2a(24409)

Description

General description

Aspartic acid(ASP)/aspartate, a non-essential amino acid, is naturally produced by mammals. ASP is one of the 20 building-block amino acids of proteins and has a one letter code, D. L-Aspartic acid can be manufactured industrially by an enzymatic process using the aspartase enzyme.

Application

L-Aspartic acid has been used:

• as an aspartame (ASP) metabolite to determine acetylcholinesterase (AChE) activity in the hippocampal homogenate of suckling rats
• as printed chemotaxis ligands to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR)
• as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) for supplementation assays of various cultured cell lines

Biochem/physiol Actions

Principal neurotransmitter for fast synaptic excitation.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves