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A7219

Sigma-Aldrich

L-Aspartic acid

from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

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Synonym(s):
(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid
Linear Formula:
HO2CCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
133.10
Beilstein/REAXYS Number:
1723530
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.75

biological source

non-animal source

Quality Level

agency

meets EP testing specifications
meets USP testing specifications

assay

98.5-101.0%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 100 mg/mL

SMILES string

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Gene Information

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This Item
11189PHR1104A9256
L-Aspartic acid from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

A7219

L-Aspartic acid

-
L-Aspartic acid BioUltra, ≥99.5% (T)

11189

L-Aspartic acid

Premium Grade
L-Aspartic acid Pharmaceutical Secondary Standard; Certified Reference Material

PHR1104

L-Aspartic acid

-
L-Aspartic acid reagent grade, ≥98% (HPLC)

A9256

L-Aspartic acid

Essential Grade
technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

assay

98.5-101.0%

assay

≥99.5% (T)

assay

-

assay

≥98% (HPLC)

color

white to off-white

color

white

color

-

color

white to off-white

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

200

impurities

endotoxin, tested

impurities

insoluble matter, passes filter test, ≤0.3% foreign amino acids

impurities

-

impurities

-

General description

Aspartic acid(ASP)/aspartate, a non-essential amino acid, is naturally produced by mammals. ASP is one of the 20 building-block amino acids of proteins and has a one letter code, D. L-Aspartic acid can be manufactured industrially by an enzymatic process using the aspartase enzyme.

Application

L-Aspartic acid has been used:
  • as an aspartame (ASP) metabolite to determine acetylcholinesterase (AChE) activity in the hippocampal homogenate of suckling rats
  • as printed chemotaxis ligands to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR)
  • as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) for supplementation assays of various cultured cell lines

Biochem/physiol Actions

Principal neurotransmitter for fast synaptic excitation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Aspartic acid
Johnson EC
reference module in biomedical sciences (2017)
Amino acid production
Eggeling L and Sahm H
Comprehensive Biotechnology (2011)
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1512, 51-63 (2016-11-26)
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and
Hongyu Ding et al.
Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)
[Figure: see text].
Shota Someya et al.
iScience, 24(2), 102090-102090 (2021-02-23)
Human pluripotent stem cells (hPSCs) have a unique metabolic signature for maintenance of pluripotency, self-renewal, and survival. Although hPSCs could be potentially used in regenerative medicine, the prohibitive cost associated with large-scale cell culture presents a major barrier to the

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