B5016

Bepridil hydrochloride

Name: Bepridil hydrochloride
Brand: SIGMA
Price: 251 USD
Availability: InStock

calcium channel blocker, powder

Synonym(s):

1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride

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100 MG

$251.00

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₄N₂O · HCl

CAS Number:

68099-86-5

Molecular Weight:

403.00

MDL number:

MFCD00065498

UNSPSC Code:

12352202

PubChem Substance ID:

24277824

NACRES:

NA.77

Key Documents

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Product Name

Bepridil hydrochloride, powder

form

powder

Quality Level

100

originator

Johnson & Johnson

SMILES string

Cl.CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

InChI key

JXBBWYGMTNAYNM-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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This Item	B4688	B2417	P4670
Sigma-Aldrich B5016 Bepridil hydrochloride	Sigma-Aldrich B4688 PBPE hydrochloride	Sigma-Aldrich B2417 Benzamil hydrochloride hydrate	Sigma-Aldrich P4670 Propafenone hydrochloride
form powder	form powder	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
originator Johnson & Johnson	originator -	originator -	originator Abbott
Gene Information human ... CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283)	Gene Information -	Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340) mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)	Gene Information human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Biochem/physiol Actions

Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na⁺-Ca²⁺ exchange; inhibits growth of brain tumor cells in vitro.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice.

Chikako Shimizu et al.

Biological & pharmaceutical bulletin, 41(7), 1049-1061 (2018-05-18)

Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with

Clinical outcome in patients with paroxysmal or persistent atrial fibrillation receiving bepridil.

Tsuyoshi Shiga et al.

Circulation journal : official journal of the Japanese Circulation Society, 75(6), 1334-1342 (2011-04-13)

It is unknown whether bepridil improves cardiovascular events in atrial fibrillation (AF) patients, so this study evaluated the clinical outcome in paroxysmal or persistent AF patients receiving bepridil. We conducted a cohort study of 284 consecutive patients who received bepridil

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Stefan Mitterreiter et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(26), 8974-8983 (2010-07-02)

The two proteases beta-secretase and gamma-secretase generate the amyloid beta peptide and are drug targets for Alzheimer's disease. Here we tested the possibility of targeting the cellular environment of beta-secretase cleavage instead of the beta-secretase enzyme itself. beta-Secretase has an

Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling.

Hiroki Takanari et al.

Journal of pharmacological sciences, 115(1), 15-26 (2010-12-16)

Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated

Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation.

Masato Murakami et al.

Journal of cardiovascular pharmacology, 56(4), 389-395 (2010-07-14)

It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated. The purpose of this study was to assess the

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Bepridil hydrochloride