This product is a technical grade of casein that cointains a mixture of alpha, beta, and kappa subunits. The approximate amount of each form present in bovine milk is as follows:
a-Casein - (s1) 12-15 g/L
a-Casein - (s2) 3-4 g/L
b-Casein - 9-11 g/L
k-Casein - 2-4 g/L
Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/137/877/c7078pis.pdf
C7078
Casein from bovine milk
powder
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Product Name
Casein from bovine milk, technical grade
biological source
bovine milk
Quality Level
grade
technical grade
form
powder
technique(s)
activity assay: suitable
electrophoresis: suitable
immunocytochemistry: suitable
mp
280 °C (dec.) (lit.)
SMILES string
[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C
InChI
1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)
InChI key
BECPQYXYKAMYBN-UHFFFAOYSA-N
Gene Information
bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099)
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This Item | C3400 | C5890 | C5679 |
|---|---|---|---|
| grade technical grade | grade - | grade - | grade - |
| technique(s) activity assay: suitable, immunocytochemistry: suitable, electrophoresis: suitable | technique(s) activity assay: suitable, electrophoresis: suitable, immunocytochemistry: suitable | technique(s) activity assay: suitable, electrophoresis: suitable, immunocytochemistry: suitable | technique(s) cell culture | insect: suitable |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form purified powder | form powder |
| biological source bovine milk | biological source bovine milk | biological source bovine milk | biological source bovine milk |
| mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) |
General description
Casein from bovine milk is a phosphoprotein. There are four main types of casein which make up approximately 80% of the total protein in bovine milk: α-s1 Casein, α-s2 Casein, β-Casein, and κ-Casein. Casein is proposed to be the main protective constituent in milk and is generally recognized as safe (GRAS) due to its naturally biocompatible and biodegradable properties.
Application
Casein from bovine milk has been used as:
- a blocking agent in immunochemistry
- a substrate to determine the casinolytic activity in disintegrin and Cerastes cerastes venom
- as a fining agent to test its effect on white wine protein stabilization
Casein from bovine milk is a phosphoprotein. There are four main types of Casein which make up approximately 80% of the total protein in bovine milk: α-s1 Casein, α-s2 Casein, β-Casein, and κ-Casein. Casein is proposed to be the main protective constituent in milk
Biochem/physiol Actions
Casein finds application in nutraceuticals and various formulations such as hydrogels, films, nano micelles, and nanoparticles due to its properties such as emulsification, foaming, gelation, water-holding capacity, and interaction with bioactive molecules through functional groups. This protein is easily available, and it protects drugs from enzymatic degradation and nontoxicity so, casein is potentially used in oral delivery systems.
Partial gastrointestinal digestion of casein is a rich source of bioactive peptides, such as β-casomorphin. However, bovine casein is not homogeneous; variants A1 and B do lead to production of β-casomorphin 7 production, while A2 does not.
Other Notes
This product is technical grade casein. When compared to partially purified casein products, the technical grade has more protein impurities present and higher fat content.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
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C Poelaert et al.
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The Drosophila mutant paraShu harbors a dominant, gain-of-function allele of the voltage-gated sodium channel gene, paralytic (para). The mutant flies display severe seizure-like phenotypes, including neuronal hyperexcitability, spontaneous spasms, ether-induced leg shaking, and heat-induced convulsions. We unexpectedly found that two
Vabitha Shetty et al.
The Journal of clinical pediatric dentistry, 35(4), 389-392 (2011-11-04)
To estimate Calcium and Phosphorus withdrawal from hydroxyapatite in the presence of bovine milk and human milk from which the following protective fractions namely Casein, Whey protein, Lactose and Milk fat have been individually removed and to compare the above
Maj Linea Vestergaard et al.
Stem cells and development, 26(21), 1566-1577 (2017-08-11)
The derivation of functional cardiomyocytes (CMs) from human embryonic stem cells (hESCs) represents a unique way of studying human cardiogenesis, including the development of CM subtypes. In this study, we investigated the development and organization of hESC-derived cardiomyocytes (hESC-CMs) and
Jennifer Ehren et al.
PloS one, 4(7), e6313-e6313 (2009-07-22)
Celiac sprue is a life-long disease characterized by an intestinal inflammatory response to dietary gluten. A gluten-free diet is an effective treatment for most patients, but accidental ingestion of gluten is common, leading to incomplete recovery or relapse. Food-grade proteases
Protocols
This procedure may be used for all Ficin products.
Related Content
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What type of casein is C7078, alpha, beta or k-casein?
1 answer-
Helpful?
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Is casein C7078 sterile, and can it function as an emulsifier?
1 answer-
C7078 is not a sterile powder. Regarding whether casein will work as an emulsifier, it has not been tested in this application.
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