The absorption wavelength for detecting dexamethasone is approximately 240 nm. However, this product has not been measured for absorption.
D2915
Dexamethasone-Water Soluble
suitable for cell culture, BioReagent
Synonym(s):
Dexamethasone – Cyclodextrin complex
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100 MG
$198.00
$198.00
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
EC Number:
200-003-9
NACRES:
NA.77
Biological source:
synthetic (organic)
Form:
solid
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Product Name
Dexamethasone-Water Soluble, suitable for cell culture, BioReagent
InChI
1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;1-12-8-16-15-5-4-13-9-14(24)6-7-21(13,2)20(15)17(25)10-22(16,3)19(12)18(26)11-23/h8-63H,1-7H2;6-7,9,12,15-17,19-20,23,25H,4-5,8,10-11H2,1-3H3/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-;12-,15+,16?,17+,19-,20-,21+,22+/m11/s1
InChI key
XEJNDGTUKUMQNG-ARJMFYCQSA-N
SMILES string
C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO.OC[C@H]5O[C@@H]6O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]9[C@H](O)[C@@H](O)[C@H](O[C@@H]9CO)O[C@H]%10[C@H](O)[C@@H](O)[C@H](O[C@@H]%10CO)O[C@H]%11[C@H](O)[C@@H](O)[C@H](O[C@@H]%11CO)O[C@H]%12[C@H](O)[C@@H](O)[C@H](O[C@@H]%12CO)O[C@H]5[C@H](O)[C@H]6O
biological source
synthetic (organic)
product line
BioReagent
form
solid
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 25 mg/mL, clear to slightly hazy
shipped in
ambient
storage temp.
room temp
Quality Level
1 of 4
This Item | D-085 | D4902 | D8893 |
|---|---|---|---|
| biological source synthetic (organic) | biological source - | biological source synthetic | biological source synthetic (organic) |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| product line BioReagent | product line - | product line BioReagent | product line BioXtra |
| form solid | form liquid | form powder | form powder |
| technique(s) cell culture | mammalian: suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) cell culture | mammalian: suitable, single cell analysis: suitable | technique(s) cell culture | mammalian: suitable |
| shipped in ambient | shipped in - | shipped in ambient | shipped in ambient |
Application
Dexamethasone-Water Soluble has been used as a component of
- Dulbecco′s modified Eagle medium based osteogenic and adipogenic medium for human mesenchymal stem cell culture[1]
- erythroid expansion media for the growth of liver, bone marrow and spleen tissues[2]
- medium 199 (M199) for hepatocyte culture[3]
Biochem/physiol Actions
Dexamethasone is an anti-inflammatory glucocorticoid[4] and a synthetic corticosteroid used for treating corneal inflammation. It inhibits the IL-1β-dependent angiogenesis.[5] Dexamethasone elicits a range of effects on cell survival, cell signaling and gene expression.[6] It favors apoptosis in chondrocytes and impairs development of bone.[7] Dexamethasone is a potential therapeutic agent as it induces apoptosis in multiple myeloma (MM) cells.[8] It elicits its functionality by lowering glucocorticoid receptor (GR) α levels and inhibits colon tumor progression.[9]
Other Notes
Contains approx. 65 mg dexamethasone per gram; balance methyl-β-cyclodextrin.
Packaging
Package size based on dexamethasone
related product
Product No.
Description
Pricing
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
England SJ, et al.
Blood, 117(9), 2708-2717 (2011)
Dexamethasone-induced apoptotic mechanisms in myeloma cells investigated by analysis of mutant glucocorticoid receptors
Sharma S and Lichtenstein A
Blood, 112(4), 1338-1345 (2008)
Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis
Stremmel W, et al.
Faseb Journal, 28(7), 3159-3170 (2014)
Dexamethasone affects cell growthapoptosis chemosensitivity of colon cancer via glucocorticoid receptor alphaNF-kappaB
He J, et al.
Testing, 8(40), 67670-67670 (2017)
The effect of temperature on the viability of human mesenchymal stem cells
Reissis Y, et al.
Stem Cell Research & Therapy, 4(6), 139-139 (2013)
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what is the wavelength of absorbance for detecting dexamethasone cyclodextrin complex in DI water in quantitative analysis?
1 answer-
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How long is Product D2915 stable in solid form?
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For certain products, the certificate of analysis may only display the Release Date, without a specified Retest, Expiration, or Use-by-Date. In such cases, the standard warranty of 1 year from the date of shipment applies. This product should remain stable in solid form for at least 1 year if stored correctly. For additional information on the warranty, refer to the terms and conditions of sale. Product Dating Information.
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D2915 is light sensitive?
1 answer-
This material is considered light sensitive and is packaged in amber glass bottles.
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What is the molecular mass of Dexamethasone-Water Soluble (D2915)?
1 answer-
This product is a multi-component item comprised of dexamethasone and (2-Hydroxypropyl)-?-cyclodextrin. The molecular weight of Dexamethasone is 392.5 g/mol. The molecular weight of the (2-Hydroxypropyl)-?-cyclodextrin is variable, but has an average molecular weight of 1,396 g/mol. There is an excess of cyclodextrin in the mixture to greatly enhance the solubility of the dexamethasone. The product is sold on the basis of the Dexamethasone content. The final product will have 55 - 75 mg of Dexamethasone per gram solid. For example, a 100mg package reporting a 75mg/gram Dexamethasone concentration would be a package of 1.81 grams. This value is reported in the Certiicate of Analysis. Please see the link below to review a sample of a specific Certificate:
https://www.sigmaaldrich.com/US/en/product/sigma/d2915#product-informationHelpful?
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What is the recommended method for storing prepared solutions of D2915 dexamethasone water-soluble?
1 answer-
The recommended method for storing prepared solutions of D2915 dexamethasone water-soluble is to store the solutions in working aliquots at -20°C.
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Is the 100mg labeled on the bottle of D2915 Dexamethasone for the total powder or the total dexamethasone?
1 answer-
Each vial contains 100 mg of dexamethasone. The mg of dexamethasone per gram is provided on the label, typically around 65 mg/g.
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How should stock solutions for item D2915-100MG be stored?
1 answer-
Stock solutions can be stored for up to 2 months at -20°C.
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Is additional solubility data available for product D2915, Dexamethasone-Water Soluble?
1 answer-
The solubility of product D2915, Dexamethasone-Water Soluble, has been tested only in water, with a solubility (turbidity) of clear to slightly hazy at 25 mg/mL in water. Additionally, It is also soluble in ethanol (25 mg/mL), DMSO (25 mg/mL), and DMF (25 mg/mL).
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Once this product has been reconstituted in water, how long can it be stored, and at what temperature?
1 answer-
Stock solutions may be stored in working aliquots at -20ºC. Please see the link below for additional information on the Water Soluble Complexes, including Dexamethasone, Water Soluble:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdfHelpful?
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Can Product D2915, Dexamethasone - Water Soluble, be filter sterilized?
1 answer-
This product can be filter sterilized through a 0.22 micron filter prior to use.
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