The solubility of this chemical in water is ≥33.4 mg/mL (test point, not an upper limit of saturation). However, it is insoluble in EtOH and DMSO.
N3501
β-Nicotinamide mononucleotide
≥95% (HPLC)
Synonym(s):
β-NMN, β-Nicotinamide ribose monophosphate, NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate
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25 MG
$163.00
100 MG
$466.00
250 MG
$981.00
500 MG
$1,710.00
About This Item
Empirical Formula (Hill Notation):
C11H15N2O8P
CAS Number:
Molecular Weight:
334.22
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
214-136-5
Beilstein/REAXYS Number:
3570187
MDL number:
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Product Name
β-Nicotinamide mononucleotide, ≥95% (HPLC)
InChI key
YYNOOWWEYJELSF-SEMCEJNYSA-N
InChI
1S/C13H19N2O6P/c1-8-9(2)13(21-11(8)7-20-22(17,18)19)15-5-3-4-10(6-15)12(14)16/h3-6,8-9,11,13H,7H2,1-2H3,(H3-,14,16,17,18,19)/t8-,9+,11+,13+/m0/s1
SMILES string
C[C@H]1[C@@H](C)[C@@H](O[C@@H]1COP(O)([O-])=O)[n+]2cccc(c2)C(N)=O
assay
≥95% (HPLC)
≥95% (spectrophotometric assay)
form
powder
solubility
H2O: soluble-50 mg/mL to clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
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1 of 4
This Item | 481907 | N7004 | 481973 |
|---|---|---|---|
| assay ≥95% (HPLC), ≥95% (spectrophotometric assay) | assay ≥99% (HPLC) | assay ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay) | assay ≥90% (HPLC), ≥93% (enzymatic) |
| solubility H2O: soluble-50 mg/mL to clear, colorless to faintly yellow | solubility water: soluble | solubility - | solubility water: 50 mg/mL |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 100 |
| storage temp. −20°C | storage temp. 15-25°C | storage temp. −20°C | storage temp. −20°C |
| form powder | form solid | form powder | form solid |
Application
β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
General description
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.
Other Notes
Note: This is the common form of NMN. Do not confuse it with α-NMN.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Tomoko Kito et al.
Drug metabolism and pharmacokinetics, 34(1), 87-94 (2018-12-12)
The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic drug interactions with trimethoprim. Trimethoprim is a more potent inhibitor
João Meireles Ribeiro et al.
Scientific reports, 8(1), 1036-1036 (2018-01-20)
Cyclic ADP-ribose (cADPR) is a messenger for Ca
C T Lauhon et al.
Journal of the American Chemical Society, 117(4), 1246-1257 (1995-02-01)
RNA molecules that specifically bind riboflavin (Rb) and beta-nicotinamide mononucleotide (NMN) have been isolated by in vitro selection. A simple structural motif containing intramolecular G-quartets was found to bind tightly to oxidized riboflavin (Kd = 1-5 micromolar). DNA versions of
Gerwyn Morris et al.
Progress in neuro-psychopharmacology & biological psychiatry, 95, 109708-109708 (2019-07-28)
Major antioxidant responses to increased levels of inflammatory, oxidative and nitrosative stress (ONS) are detailed. In response to increasing levels of nitric oxide, S-nitrosylation of cysteine thiol groups leads to post-transcriptional modification of many cellular proteins and thereby regulates their
Jun Yoshino et al.
Cell metabolism, 14(4), 528-536 (2011-10-11)
Type 2 diabetes (T2D) has become epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such pathway is mediated by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD(+) biosynthesis, and the NAD(+)-dependent
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What is the solubility of item N3501, β-Nicotinamide mononucleotide?
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ref N3501: how many pills in the pack of 25mg NMN?
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This product is a bulk powder. Note that this product is intended for research use only. It is not suitable for human or veterinary use.
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