SRP5049

MET (958-end), active, GST tagged from rat

Name: MET (958-end), active, GST tagged from rat
Brand: SIGMA
Price: 430 USD

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

HGFR

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10 μG

$430.00

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

Key Documents

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recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO^® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

39-53 nmol/min·mg

mol wt

~74 kDa

NCBI accession no.

X96786

shipped in

dry ice

storage temp.

−70°C

Gene Information

rat ... Met(24553)

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This Item	SRP5302	SRP5091	T0203
Sigma-Aldrich SRP5049 MET (958-end), active, GST tagged from rat	Sigma-Aldrich SRP5302 MET (M1250T), active, GST tagged human	Sigma-Aldrich SRP5091 TGFβR1 (80-end), active, GST tagged human	Sigma-Aldrich T0203 TGFβR2 (190-end), active, GST tagged human
assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells
form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
mol wt ~74 kDa	mol wt ~81 kDa	mol wt ~66 kDa	mol wt ~68 kDa
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
specific activity 39-53 nmol/min·mg	specific activity 148-222 nmol/min·mg	specific activity 2.5-3.5 nmol/min·mg	specific activity 6-8 nmol/min·mg

General description

MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kd (alpha) and 145 kd (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

P273-1

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Biosynthesis of the protein encoded by the c-met proto-oncogene.

S Giordano et al.

Oncogene, 4(11), 1383-1388 (1989-11-01)

The proto-oncogene c-met encodes a transmembrane protein with structural features of a growth factor receptor. We have previously shown that the c-met protein (c-Met) is a heterodimer of two disulphide linked chains of 50 kd (alpha) and 145 kd (beta).

Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene.

A Iyer et al.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1(2), 87-95 (1990-02-01)

A 6.7-kilobase met complementary DNA (cDNA) was isolated from a pcD cDNA library prepared from C3H mouse fibroblast cell line polyadenylated RNA. Sequence analysis of 6.7-kilobase met cDNA insert revealed that it contained the entire open reading frame and shared

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MET (958-end), active, GST tagged from rat