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Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: a chemical model for possible biologically relevant properties of molybdenum-containing enzymes.

Bioorganic & medicinal chemistry letters (2012-05-02)
Mladen Litvić, Maja Regović, Karolina Smic, Marija Lovrić, Mirela Filipan-Litvić
ABSTRACT

Mo(VI) and Mo(V) salts both react selectively with Hantzsch esters to produce substitute pyridines in good-to-excellent yield (75-99%). The remarkable reactivity and selectivity of MoOCl(4) under reflux of acetonitrile and MoCl(5) in dichloromethane at room temperature encouraged us to propose that molybdenum-containing enzymes (such as xanthine or aldehyde oxidase) also participate to some degree in the metabolism of 1,4-dihydropyridine drugs in the liver analogous to NADH in the respiratory chain.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Molybdenum(V) chloride, 95%
Sigma-Aldrich
Molybdenum(V) chloride, anhydrous, powder, 99.99% trace metals basis (excluding W)
Sigma-Aldrich
Molybdenum(VI) tetrachloride oxide, 97%

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