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MilliporeSigma

67028

Methylglyoxal solution

technical, ~40% in H2O

Synonym(s):

Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde

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100 ML

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About This Item

Linear Formula:
CH3COCHO
CAS Number:
78-98-8
Molecular Weight:
72.06
Beilstein/REAXYS Number:
906750
MDL number:
MFCD00006960
UNSPSC Code:
12352100
PubChem Substance ID:
329760261
NACRES:
NA.22

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grade

technical

Quality Level

200

concentration

~40% in H2O

density

1.19 g/mL at 20 °C

functional group

aldehyde
ketone

storage temp.

2-8°C

SMILES string

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChI key

AIJULSRZWUXGPQ-UHFFFAOYSA-N

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1 of 4

This Item
M0252W296902G5882
Methylglyoxal solution technical, ~40% in H2O

Sigma-Aldrich

67028

Methylglyoxal solution

Methylglyoxal solution ~40% in H2O

Sigma-Aldrich

M0252

Methylglyoxal solution

Pyruvaldehyde solution 40 wt. % in H2O

Sigma-Aldrich

W296902

Pyruvaldehyde solution

Glutaraldehyde solution Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative

Sigma-Aldrich

G5882

Glutaraldehyde solution

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

density

1.19 g/mL at 20 °C

density

1.17 g/mL at 25 °C (lit.)

density

1.178 g/mL at 25 °C

density

-

grade

technical

grade

-

grade

-

grade

-

concentration

~40% in H2O

concentration

~40% (enzymatic), ~40% in H2O

concentration

40 wt. % in H2O

concentration

25% in H2O

functional group

aldehyde

functional group

-

functional group

-

functional group

-

General description

Methylglyoxal is a toxic endogenous by-product of glycolysis.[1] It is a reactive dicarbonyl compound that promotes non-enzymatic glycation of proteins to yield irreversible advanced glycated end products, leading to the cross-linking or degradation of proteins.[2]

Application

Methylglyoxal solution is used in cytotoxic studies.[1][3][2]

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7445V
WXBF5825V
WXBF4922V
WXBF4459V
WXBF3145V

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Potential Neuroprotective and Anti-Apoptotic Properties of a Long-Lasting Stable Analog of Ghrelin: an In Vitro Study Using SH-SY5Y Cells.
Popelova A, et al.
Physiological Research, 67(2), 339-346 (2018)
Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors.
Al?Balas Q A, et al.
Drug Development Research, 79(2), 58-69 (2018)
Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1, 2-diamino-4, 5-methylenedioxybenzene.
Ogasawara Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1029, 102-105 (2016)
Georg T Wondrak et al.
Biochemical pharmacology, 63(3), 361-373 (2002-02-21)
Tissue deterioration and aging have long been associated with the accumulation of chemically induced protein and DNA damage. Reactive oxygen species (ROS) and reactive carbonyl species (RCS), especially alpha-dicarbonyl compounds, are key mediators of damage caused by oxidative stress, glycation
Wei-Hsuan Hsu et al.
Toxicology and applied pharmacology, 272(3), 842-851 (2013-08-21)
Methylglyoxal (MG) is a toxic-glucose metabolite and a major precursor of advanced glycation endproducts (AGEs). MG has been reported to result in inflammation by activating receptor for AGEs (RAGE). We recently found that Monascus-fermented metabolite monascin acts as a novel
View All Related Papers

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