This product has not been tested for suitability in cell culture, but has been used in culture applications by other scientists based on cited literature. The material is expected to be compatible with BY-2 cell culture, provided stock solutions are filter-sterilized before use. Should a cell culture qualified product be required, see the link below to review product T1270, a cell culture tested Thiamine HCl:
https://www.sigmaaldrich.com/product/sigma/T1270
T4625
Thiamine hydrochloride
reagent grade, ≥99% (HPLC)
Synonym(s):
Aneurine hydrochloride, Vitamin B1 hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Available to ship TODAY | $25.10 |
10 g | Available to ship TODAY | $47.40 |
25 g | Available to ship TODAY | $77.80 |
100 g | Available to ship TODAY | $110.00 |
250 g | Available to ship TODAY | $246.00 |
1 kg | Available to ship TODAY | $662.00 |
About This Item
Empirical Formula (Hill Notation):
C12H17ClN4OS · HCl
CAS Number:
Molecular Weight:
337.27
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
34058006
UNSPSC Code:
12352209
EC Number:
200-641-8
MDL number:
Beilstein/REAXYS Number:
3851771
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biological source
synthetic (organic)
Quality Segment
grade
reagent grade
assay
≥99% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
white
mp
250 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL, clear, colorless
SMILES string
CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
InChI
1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
InChI key
DPJRMOMPQZCRJU-UHFFFAOYSA-M
General description
Thiamine is a water-soluble vitamin-B complex. Structurally, it possesses a five-membered thiazolium ring and a six-membered amino-pyrimidine ring connected by a methyl group. Thiamine is naturally available in fruits, vegetables, poultry, eggs.
Application
Thiamine hydrochloride has been used as a vitamin supplement to the holidic medium and in bacterial growth medium.
Biochem/physiol Actions
Thiamine is an essential coenzyme in carbohydrate metabolism. Deficiency of thiamine causes beriberi, a neurological and cardiovascular disease. Thiamine is administered in case of deficiency, either due to reduced intake or synthesis. Congenital defect in the thiamine transporter gene SLC19A2 causes thiamine-responsive megaloblastic anemia syndrome (TRMA). Thiamine mimics acetylcholine in brain and possible exerts a role in Alzheimer′s disease. Thiamine deficiency in ruminants causes polioencephalomalacia.
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This Item | |||
|---|---|---|---|
| description reagent grade, ≥99% (HPLC) | description European Pharmacopoeia (EP) Reference Standard | description ≥98%, FCC, FG | description tested according to Ph. Eur. |
| grade reagent grade | grade pharmaceutical primary standard | grade Halal, Kosher, FG | grade - |
| technique(s) HPLC: suitable | technique(s) - | technique(s) - | technique(s) - |
| assay ≥99% (HPLC) | assay - | assay ≥98% | assay 98.5-101.0% anhydrous basis |
| biological source synthetic (organic) | biological source - | biological source synthetic | biological source synthetic |
| form powder | form - | form powder or crystals | form solid |
| solubility H2O: 50 mg/mL, clear, colorless | solubility - | solubility H2O: 1 g/10 mL, clear, colorless | solubility propylene glycol: soluble, alcohol: soluble 1 gm in 100 ml (95%), diethyl ether: insoluble, hexane: insoluble, benzene: insoluble, glycerol: soluble 1 gm in 18 ml, water: soluble 1 g/mL, alcohol: soluble 1 gm in 315 ml (Absolute), methanol: very soluble, chloroform: insoluble |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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EST il adapté en tant que supplément dans une culture cellulaire de BY-2 CELL
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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