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Fibroblast Growth Factor-8b from mouse

Name: Fibroblast Growth Factor-8b from mouse
Brand: SIGMA
Price: 805.8 CAD

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

FGF-8b

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Size/SKU	Availability	Price
25 μg	Please contact Customer Service for Availability	$948.00 $805.80

About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD01323276

$805.80

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Properties

biological source

mouse

Quality Segment

100

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

15-60 ng/mL

mol wt

calculated mol wt 23.6 kDa, predicted mol wt 22 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

P37237

storage temp.

−20°C

Gene Information

mouse ... Fgf8(14179)

Description

General description

Fibroblast growth factor 8 (FGF8) is a member of the FGF family, and was initially cloned from androgen-dependent mouse mammary carcinoma cell line. Alternative splicing of this gene produces four different isoforms mainly, FGF8a, FGF8b, FGF8e and FGF8f.[1]

Application

Fibroblast Growth Factor-8b from mouse has been used-

for subgerminal cavity injection in fertilized quail, chicken, turtle and emu eggs[2]
in the induction of neural differentiation in stem cells from Human Exfoliated Deciduous teeth (SHED)[3] and
in experiments conducted on fertilized hens′ eggs, where FGF8 induced SOX3 gene.[4]

Biochem/physiol Actions

FGF-8b is involved in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system. FGF-8b activates the "c" splice form of FGFR-2, FGFR-3, and FGFR-4.

Fibroblast growth factor 8b (FGF8b) isoform of FGF8 has the most potent angiogenic and tumorigenic properties. In prostate cancer, it is responsible for angiogenesis, tumorigenesis and invasion. Exogenous expression of this gene in prostate epithelium leads to prostatic intraepithelial neoplasia (PIN). It also interacts with pattern recognition receptor long pentraxin-3 (PTX3), which is involved in local inflammation.[1]

Physical form

Lyophilized from a 0.2μm filtered solution in 20mM MOPS, 0.1M sodium sulfate, 0.02% Brij-35, pH 7 containing 50ug of BSA per 1μg as a carrier protein

Analysis Note

The biological activity is measured by its ability to stimulate proliferation of NR6R-3T3 fibroblasts.

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This Item	F7301	F3685	F8924
Sigma-Aldrich F6926 Fibroblast Growth Factor-8b from mouse	Sigma-Aldrich F7301 Fibroblast Growth Factor-18 human	Sigma-Aldrich F3685 Fibroblast Growth Factor-Basic	Sigma-Aldrich F8924 Fibroblast Growth Factor-10 human
assay >97% (SDS-PAGE)	assay >95% (SDS-PAGE and HPLC)	assay ≥97% (SDS-PAGE)	assay >97% (SDS-PAGE)
biological source mouse	biological source human	biological source human	biological source human
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
Gene Information mouse ... Fgf8(14179)	Gene Information human ... FGF18(8817)	Gene Information human ... FGF2(2247)	Gene Information human ... FGF10(2255)

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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