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F6926

Fibroblast Growth Factor-8b from mouse

Name: Fibroblast Growth Factor-8b from mouse
Brand: SIGMA
Price: 586.5 USD
Availability: InStock

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Sinónimos:

FGF-8b

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A ustedes/SKU	Disponibilidad	Precio
25 μg	Disponible para enviar HOYdesdeMILWAUKEE	$690.00 $586.50

Acerca de este artículo

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD01323276

$586.50

Precio de catálogo$690.00Ahorre 15 %

Promoción solo por Internet

Disponible para enviar HOYDetalles

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Propiedades

biological source

mouse

Quality Segment

100

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

15-60 ng/mL

mol wt

calculated mol wt 23.6 kDa, predicted mol wt 22 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

P37237

storage temp.

−20°C

Gene Information

mouse ... Fgf8(14179)

Descripción

General description

Fibroblast growth factor 8 (FGF8) is a member of the FGF family, and was initially cloned from androgen-dependent mouse mammary carcinoma cell line. Alternative splicing of this gene produces four different isoforms mainly, FGF8a, FGF8b, FGF8e and FGF8f.[1]

Application

Fibroblast Growth Factor-8b from mouse has been used-

for subgerminal cavity injection in fertilized quail, chicken, turtle and emu eggs[2]
in the induction of neural differentiation in stem cells from Human Exfoliated Deciduous teeth (SHED)[3] and
in experiments conducted on fertilized hens′ eggs, where FGF8 induced SOX3 gene.[4]

Biochem/physiol Actions

FGF-8b is involved in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system. FGF-8b activates the "c" splice form of FGFR-2, FGFR-3, and FGFR-4.

Fibroblast growth factor 8b (FGF8b) isoform of FGF8 has the most potent angiogenic and tumorigenic properties. In prostate cancer, it is responsible for angiogenesis, tumorigenesis and invasion. Exogenous expression of this gene in prostate epithelium leads to prostatic intraepithelial neoplasia (PIN). It also interacts with pattern recognition receptor long pentraxin-3 (PTX3), which is involved in local inflammation.[1]

Physical form

Lyophilized from a 0.2μm filtered solution in 20mM MOPS, 0.1M sodium sulfate, 0.02% Brij-35, pH 7 containing 50ug of BSA per 1μg as a carrier protein

Analysis Note

The biological activity is measured by its ability to stimulate proliferation of NR6R-3T3 fibroblasts.

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Este artículo	F8424	P5739	F4537
Sigma-Aldrich F6926 Fibroblast Growth Factor-8b from mouse	Sigma-Aldrich F8424 Fibroblast Growth Factor-4 human	Sigma-Aldrich P5739 Placenta Growth Factor-2 from mouse	Sigma-Aldrich F4537 Fibroblast Growth Factor-5 human
assay >97% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay >97% (SDS-PAGE)	assay ≥97% (SDS-PAGE and N-terminal analysis)
biological source mouse	biological source human	biological source mouse	biological source human
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in E. coli
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
impurities endotoxin, tested	impurities <1 EU/μg (LAL test)	impurities endotoxin, tested	impurities endotoxin, tested

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c