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Transforming Growth Factor-β2 human

Name: Transforming Growth Factor-&#946;2 human
Brand: SIGMA
Price: 580 USD
Availability: InStock

≥97% (electrophoresis), recombinant, expressed in NSO cells, powder, suitable for cell culture

Synonym(s):

hTGF-β2, TGF-β2

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Size/SKU	Availability	Price
2 μg	Available to ship TODAYfromMILWAUKEE	$580.00
10 μg	Available to ship TODAYfromMILWAUKEE	$1,760.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00163957

Biological source:

human

Recombinant:

expressed in NSO cells

Assay:

≥97% (electrophoresis)

Form:

powder

Mol wt:

25 kDa

Impurities:

≤1 EU/μg

$580.00

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Properties

Product Name

Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture

biological source

human

Quality Segment

200

recombinant

expressed in NSO cells

assay

≥97% (electrophoresis)

form

powder

potency

0.04 ng/mL ED₅₀

quality

endotoxin tested

mol wt

25 kDa

packaging

pkg of 10 μg, pkg of 2 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

suitability

suitable for

UniProt accession no.

P61812

storage temp.

−20°C

Gene Information

human ... TGFB2(7042), TGFBR2(7048)

Description

General description

The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41. The encoded protein is localized to extracellular matrix. TGF-β2 is a member of the TGF-β superfamily. TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.

Application

Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells. It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.

Biochem/physiol Actions

TGF-β2 is known to stimulate cell growth, differentiation, migration and survival. TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis. TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells. TGF-β is associated with the process of tumor development, progression and metastasis. TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.

Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin

Analysis Note

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

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This Item	H8666	T5425	T7039
Sigma-Aldrich T2815 Transforming Growth Factor-β2 human	Sigma-Aldrich H8666 Transforming Growth Factor-β2 human	Sigma-Aldrich T5425 Transforming Growth Factor-β3 human	Sigma-Aldrich T7039 Transforming Growth Factor-β1 human
description TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture	description TGF-β2, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture	description TGF-β3, recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture	description TGF-β1, recombinant, expressed in CHO cells, powder, suitable for cell culture
biological source human	biological source human	biological source human	biological source human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
recombinant expressed in NSO cells	recombinant expressed in HEK 293 cells	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in CHO cells
assay ≥97% (electrophoresis)	assay ≥95% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
Quality Level 200	Quality Level 200	Quality Level 100, 200	Quality Level 200
form powder	form lyophilized powder	form powder	form powder

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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