46401

Cicloheximida

PESTANAL^®, analytical standard

• Sinônimo(s): 3-[2-(3,5-Dimetil-2-oxociclohexil)-2-hidroxietil]glutarimida, Actidiona, Naramycin A
• Fórmula empírica (Notação de Hill): C₁₅H₂₃NO₄
• Número CAS: 66-81-9
• Peso molecular: 281.35
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329757163
• EC Number: 200-636-0
• Beilstein/REAXYS Number: 88868
• MDL number: MFCD00082346

Propriedades

• Nome do produto: Cicloheximida, PESTANAL^®, analytical standard
• InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• SMILES string: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• grade: analytical standard
• description: mixture of stereo isomers
• product line: PESTANAL^®
• assay: ≥95% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• solubility: H₂O: slightly soluble
• antibiotic activity spectrum: fungi
• application(s): agriculture; cleaning products; cosmetics; environmental; food and beverages; personal care
• format: neat
• mode of action: protein synthesis | interferes
• storage temp.: −20°C
• Quality Level: 100

Descrição

Biochem/physiol Actions

Modo de ação: Inibição da tradução em eucariotos, o que leva à interrupção do crescimento celular e à morte celular. A CHX é amplamente utilizada para seleção de cepas de levedura e fungos resistentes à CHX, inibição controlada da síntese de proteínas para detectar proteínas de vida curta e superindução da expressão proteica, bem como para indução da apoptose ou facilitação da indução da apoptose por receptores de morte celular.

Espectro da atividade: Ativo contra leveduras e fungos como Candida, Aspergillus, Saccharomyces, Penicillium

Application

Cycloheximide may find the following uses:

• To evaluate the antifungal efficacy and safety of cycloheximide as a supplement in Optisol-GS
• To study the effect of cycloheximide on leaf-cutting ant workers
• To study the effect of streptomycin, cycloheximide, fungizone, captan, carbofuran, cygon, and pentachloronitrobenzene on soil microorganisms
• To study the fungal control of nitrous oxide production in a semiarid grassland
• To study the activity and degradation of streptomycin and cycloheximide in soil

General description

Cycloheximide is an antibiotic having significant antifungal properties. It is produced by streptomycin-producing strains of Streptomyces griseus and acts by inhibiting protein synthesis. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. It is used as a fungicide.
As per Regulation (EC) No 1107/2009, repealing the directive 91/414, cycloheximide is not approved for use in the European Union (EU).

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H300,H341,H360D,H411
• pcodes: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges