K1751

Ketoprofen

≥98% (TLC)

• Synonym(s): 2-(3-Benzoylphenyl)propionic acid
• Empirical Formula (Hill Notation): C₁₆H₁₄O₃
• CAS Number: 22071-15-4
• Molecular Weight: 254.28
• Número EC: 244-759-8
• Número MDL: MFCD00055790
• ID de substância PubChem: 57654315
• NACRES: NA.77

Properties

• fonte biológica: synthetic
• Nível de qualidade: 200
• teor: ≥98% (TLC)
• forma: powder
• solubilidade: ethanol: 50 mg/mL, clear, colorless to yellow
• originador: Bayer
• SMILES string: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
• InChI key: DKYWVDODHFEZIM-UHFFFAOYSA-N
• Gene Information: human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

Description

Descrição geral

Ketoprofen belongs to the class of 2-arylpropionic acid.

Aplicação

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Embalagem

1, 5, 25, 100 g

Ações bioquímicas/fisiológicas

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Características e benefícios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges