PHR1140

Ketorolac-Tromethamin

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): Ketorolac Tris-salz, (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-carbonsäure, Toradol
• Empirische Formel (Hill-System): C₁₅H₁₃NO₃ · C₄H₁₁NO₃
• CAS-Nummer: 74103-07-4
• Molekulargewicht: 376.40
• NACRES: NA.24
• PubChem Substance ID: 329823160
• UNSPSC Code: 41116107
• MDL number: MFCD00887595

Eigenschaften

• Produktname: Ketorolac-Tromethamin, Pharmaceutical Secondary Standard; Certified Reference Material
• InChI: 1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
• SMILES string: NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
• InChI key: BWHLPLXXIDYSNW-UHFFFAOYSA-N
• grade: certified reference material; pharmaceutical secondary standard
• agency: traceable to Ph. Eur. Y0000486; traceable to USP 1356665
• API family: ketorolac
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• Quality Level: 300
• Gene Information: human ... PTGS1(5742), PTGS2(5743)

Beschreibung

Other Notes

Die Werte der Analyten sind Lot-spezifisch.

Dieses zertifizierte Referenzmaterial (CRM) wurde gemäss den Normen ISO/IEC 17025 und ISO Guide 34 produziert und zertifiziert.

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

To see an example of a Certificate of Analysis for this material enter LRAA7191 in the slot below. This is an example certificate only and may not be the lot that you receive.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Ketorolac Tromethamine may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[1][2] using reversed-phase high-performance liquid chromatography[1] and spectrophotometric technique.[2]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ketorolac Tromethamine belongs to the class of non-steroidal anti-inflammatory drugs, and its mode of action involves the inhibition of the bodily synthesis of prostagladins. It exhibits anti-inflammatory, antipyretic and analgesic effects.[1]

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable