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Merck

50531

グリチルリチン酸 アンモニウム塩 glycyrrhiza root (カンゾウ)由来

≥95.0% (NT)

別名:

3-O-(2-O-β-D-グルコピラヌロノシル-α-D-グルコピラヌロノシル)-18β-グリチルレチン酸 アンモニウム塩, グリシルリジン

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この商品について

化学式:
C42H62O16 · NH3
CAS番号:
分子量:
839.96
UNSPSC Code:
12352106
NACRES:
NA.76
PubChem Substance ID:
EC Number:
258-887-7
Beilstein/REAXYS Number:
3897076
MDL number:

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製品名

グリチルリチン酸 アンモニウム塩 glycyrrhiza root (カンゾウ)由来, ≥95.0% (NT)

InChI

1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1

InChI key

ILRKKHJEINIICQ-OOFFSTKBSA-N

SMILES string

N.CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)C(O)=O

assay

≥95.0% (NT)

optical activity

[α]20/D +48±4°, c = 1% in ethanol: water (1:1)

sweetness

50 × sucrose

impurities

≤7% water

Quality Level

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当該品目
G213791443356780
Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

assay

≥95.0% (NT)

assay

≥70% (HPLC)

assay

≥90.0% (HPLC)

assay

≥95% (HPLC)

impurities

≤7% water

impurities

-

impurities

-

impurities

-

optical activity

[α]20/D +48±4°, c = 1% in ethanol: water (1:1)

optical activity

-

optical activity

-

optical activity

-

sweetness

50 × sucrose

sweetness

-

sweetness

-

sweetness

-

Biochem/physiol Actions

Glycyrrhiza属の種(カンゾウ)の甘味のある根に含まれる生物活性成分です。抗ウイルス性。

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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試験成績書(COA)

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Beilei Liu et al.
Oxidative medicine and cellular longevity, 2019, 1703709-1703709 (2020-01-14)
High mobility group box 1 (HMGB1) participates actively in oxidative stress damage and the latter relates closely to diabetic complications, including poor implant osseointegration. This article is aimed at investigating the effects of HMGB1 on dysfunction of bone marrow stromal
Guannan Li et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 109, 182-190 (2017-08-05)
The potential of licorice dietary supplements to interact with drug metabolism was evaluated by testing extracts of three botanically identified licorice species (Glycyrrhiza glabra L., Glycyrrhiza uralensis Fish. ex DC. and Glycyrrhiza inflata Batalin) and 14 isolated licorice compounds for
Oluwaseun O Ojo et al.
American journal of physiology. Lung cellular and molecular physiology, 309(11), L1354-L1366 (2015-10-04)
High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) protein that binds Toll-like receptors (e.g., TLR4) and the receptor for advanced glycated end products (RAGE). The direct effects of HMGB1 on airway structural cells are not fully
Yu Okuma et al.
Neuropharmacology, 85, 18-26 (2014-05-27)
Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the release of high mobility group box-1 (HMGB1), a protein considered representative of damage-associated molecular patterns. We found that GL bound HMGB1 but not RAGE
Guangyi Zhao et al.
PloS one, 14(9), e0222369-e0222369 (2019-09-29)
Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis of tendinopathy is unclear. Here we report that high mobility group box1 (HMGB1) is released to the tendon extracellular matrix and initiates an inflammatory cascade in response to

質問

1–3/3 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      役に立ちましたか?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      役に立ちましたか?

  3. What is the solubility of product 50531 (Glycyrrhizic acid ammonium salt from glycyrrhiza root - licorice)?

    1 回答
    1. Solubility testing is not conducted. However, information from literature and web sources indicates the following:
      1.Slightly soluble in water
      2.Soluble in 1 M NH4OH (50 mg/ml)
      3.Soluble in Acetic Acid
      4.Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO
      5.Very slightly soluble in anhydrous ethanol
      6.It dissolves in dilute solutions of acids and of alkali hydroxides

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