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Merck

D2438

ジメチルスルホキシド

sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Dimethyl sulfoxide

別名:

DMSO, メチルスルホキシド

ログインで組織・契約価格をご覧ください。

サイズを選択してください

50 ML

¥34,700

5 X 10 ML

¥36,600

¥34,700


在庫あり出荷可能詳細



この商品について

化学式:
(CH3)2SO
CAS番号:
分子量:
78.13
UNSPSC Code:
12191502
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-664-3
Beilstein/REAXYS Number:
506008
MDL number:
Grade:
BioPerformance Certified
Technique(s):
cell culture | hybridoma: suitable, cryopreservation: suitable
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)

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InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

SMILES string

CS(C)=O

grade

BioPerformance Certified

agency

USP XXIV, meets EP testing specifications, meets USP testing specifications

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

sterility

sterile-filtered

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

technique(s)

cell culture | hybridoma: suitable, cryopreservation: suitable

impurities

≤0.1% water

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H2O: miscible (completely)

density

1.10 g/mL (lit.)

Quality Level

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当該品目
4164034869472301
Quality Level

400

Quality Level

300

Quality Level

100

Quality Level

200

grade

BioPerformance Certified

grade

ACS reagent, puriss. p.a.

grade

-

grade

ACS reagent

technique(s)

cell culture | hybridoma: suitable, cryopreservation: suitable

technique(s)

-

technique(s)

HPLC: suitable

technique(s)

-

solubility

H2O: miscible (completely)

solubility

-

solubility

-

solubility

-

form

liquid

form

liquid

form

liquid

form

liquid

vapor pressure

0.42 mmHg ( 20 °C)

vapor pressure

0.42 mmHg ( 20 °C)

vapor pressure

0.42 mmHg ( 20 °C)

vapor pressure

0.42 mmHg ( 20 °C)

Application

ジメチルスルホキシドは、in vivoで肝星細胞(HSC)を培養し、活性化を誘導するための溶媒対照として使用されています。[1][1]また、髄核(NP)細胞に対するフェルラ酸(FA)の細胞毒性を調べるストック溶液の調製にも使用されています。[2]

Disclaimer

容易に過冷却状態となり、室温で徐々に再融解します。凝固している場合は室温に放置すると、劣化させることなく液体に戻すことができます。

Features and Benefits

便利なセプタムねじ蓋アンバーボトルにパッケージされた、すぐに使用できる濾過滅菌済みの製品です。 USPおよびEPの試験要件を満たしています。

General description

ジメチルスルホキシド(DMSO)は非プロトン性溶媒です。水に溶けない治療用分子や毒性分子は、しばしばDMSOに溶けます。DMSOなどの凍結保存剤と液体窒素を併用する方法は、細胞の保存に幅広く使用されます。DMSOは、さまざまな分子のストック溶液の調製に使用されており、また、これらの分子のコントロールとしても使用されます。細胞遊走アッセイにおいて、遊走後の細胞の溶解に使用されています。また、BPC-試験済みのDMSOは、バイオテクノロジーおよび組織エンジニアリングアプリケーションにおける要求を満たしています。

保管分類

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

第4類:引火性液体 + 第三石油類 + 危険等級III + 水溶性液体

fsl

名称等を表示すべき危険物及び有害物

ishl_indicated

名称等を通知すべき危険物及び有害物

ishl_notified

D2438-CH: + D2438-VAR: + CR20042-500ML: + D2438-PROC: + D2438-50ML-CH: + D2438-50ML: + D2438-5X10ML: + D2438-500ML: + D2438-BULK: + D2438-VAR-C:

jan


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試験成績書(COA)

Lot/Batch Number

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特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

A Oguro-Ando et al.
Molecular psychiatry, 20(9), 1069-1078 (2014-10-15)
Rare maternally inherited duplications at 15q11-13 are observed in ~1% of individuals with an autism spectrum disorder (ASD), making it among the most common causes of ASD. 15q11-13 comprises a complex region, and as this copy number variation encompasses many
Caroline Godfrey et al.
Human molecular genetics, 24(15), 4225-4237 (2015-05-03)
Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of dystrophin protein. Despite this, the relationship between restoring dystrophin to established dystrophic muscle and its ability to induce clinically relevant changes in muscle
Claudia C Faria et al.
Cancer research, 75(1), 134-146 (2014-11-14)
Medulloblastoma is the most common malignant pediatric brain tumor, with metastases present at diagnosis conferring a poor prognosis. Mechanisms of dissemination are poorly understood and metastatic lesions are genetically divergent from the matched primary tumor. Effective and less toxic therapies
Phillip McDonagh et al.
Veterinary microbiology, 174(3-4), 438-447 (2014-12-04)
Feline infectious peritonitis (FIP), a feline coronavirus (FCoV) induced disease, is almost invariably fatal with median life expectancy measured in days. Current treatment options are, at best, palliative. The objectives of this study were to evaluate a panel of nineteen
Mike Clements et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(2), 445-461 (2014-05-09)
Human stem cell derived cardiomyocytes (hESC-CM) provide a potential model for development of improved assays for pre-clinical predictive drug safety screening. We have used multi-electrode array (MEA) analysis of hESC-CM to generate multi-parameter data to profile drug impact on cardiomyocyte

資料

Overview of good cell banking practices for cell line cryopreservation purposes.

質問

1–10/16 質問  
  1. For D2438-5X10ML, do they come in glass ampoule or bottle with lid?

    1 回答
    1. Yes, both package sizes have a septum cap closure as shown in the image below:

      役に立ちましたか?

  2. Hi, what is the difference between DMSO product# D2438 and D2650? What is Hybri-Max vs. BioPerformance certified and meets USP testing specification?

    1 回答
    1. Both D2438 and D2650 are suitable for cell culture. The D2650 is part of the Hybri-Max™ product line. Hybri-Max products have been tested for use in hybridoma creation and culture. The D2438 is part of the BioPerformance Certified group of products. These products are tested and optimized for use in biological applications. For this product and a number of others, this includes testing to meet USP and EP guidelines. Please see the links below to review a sample Certificate of Analysis for each item.
      D2650
      https://www.sigmaaldrich.com/product/sigma/d2438#product-documentation
      D2438
      https://www.sigmaaldrich.com/product/sigma/d2650#product-documentation

      役に立ちましたか?

  3. Purity grade of the product ?

    1 回答
    1. The purity of this product is listed on the lot specific Certificate of Analysis. Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate:
      https://www.sigmaaldrich.com/product/sigma/d2438#product-documentation

      役に立ちましたか?

  4. El DMSO es sensible a la luz, hay que tomar alguna precaución al respecto?

    1 回答
    1. This product is packaged in amber glass and is protected from light. The 10 mL size is packaged in a sealed ampule. Once opened, any content that is not used should also be stored in amber glass. For long term storage, the material may also be stored under inert gas to preserve the shelf life. Note that this material has a tendency to absorb water. Containers should be tightly sealed.

      役に立ちましたか?

  5. what are the storing conditions?

    1 回答
    1. This product is stored at room temperature. Store in a well-ventilated place. Keep cool. Please see the Material Safety Data Sheet for more information: https://www.sigmaaldrich.com/sds/sigma/d2438.

      役に立ちましたか?

  6. What is the difference between products D2438 and D8418?

    1 回答
    1. The D2438 is a BioPerformance Certified grade product suitable for cell culture, hybridoma creation, and cryopreservation. It is intended for research use only but does meet USP and EP testing requirements. The D8418 is a molecular biology-grade product suitable for DNA sequencing, PCR, and transfection. It has been tested for RNAse and DNAse. The products can be selected based on the application.

      Please view the sample Certificate of Analysis for each product to see the testing specifications associated with that item:
      https://www.sigmaaldrich.com/certificates/Graphics/COfAInfo/fluka/pdf/PDF734068.pdf
      https://www.sigmaaldrich.com/coa/SIGMA/D2438/RNBL8837

      役に立ちましたか?

  7. What is the basis for the endotoxin specification for Dimethyl sulfoxide (DMSO)?

    1 回答
    1. The industry standard for 'endotoxin free' is less than 1 EU/mL.

      役に立ちましたか?

  8. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 回答
    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      役に立ちましたか?

  9. What is the molarity of DMSO?

    1 回答
    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

      役に立ちましたか?

  10. Where does DMSO come from?

    1 回答
    1. DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

      役に立ちましたか?

1–10/16 質問  

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