SCP0093

Caspase Inhibitor

Name: Caspase Inhibitor
Brand: SIGMA
Price: 316 USD

≥95% (HPLC)

Synonym(s):

Ac-LETD-CHO, caspase 8 inhibitor, caspase 9 inhibitor

Slide 1 of 1

Select a Size

5 MG

$316.00

Usually ships in 2 weeks.

About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₄N₄O₁₀

Molecular Weight:

502.52

NACRES:

NA.32

UNSPSC Code:

12352200

Key Documents

View All Documentation

Product Name

Caspase Inhibitor, ≥95% (HPLC)

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Gene Information

human ... CASP8(841), CASP9(842)

Related Categories

Bioactive Small Molecule Inhibitors

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	SCP0095	627610	SCP0094
Sigma-Aldrich SCP0093 Caspase Inhibitor	Sigma-Aldrich SCP0095 Caspase Inhibitor	Sigma-Aldrich 627610 Caspase Inhibitor I	Sigma-Aldrich SCP0094 Caspase Inhibitor
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay -	assay ≥95% (HPLC)
Gene Information human ... CASP8(841), CASP9(842)	Gene Information human ... CASP9(842)	Gene Information -	Gene Information human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842)
form lyophilized	form lyophilized	form solid	form lyophilized
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
storage condition protect from light	storage condition protect from light	storage condition OK to freeze, desiccated	storage condition protect from light
composition Peptide Content, ≥80%	composition Peptide Content, ≥80%	composition -	composition Peptide Content, ≥80%

Biochem/physiol Actions

The peptide Ac-Leu-Glu-Thr-Asp-al, or Ac-LETD-CHO, is a known caspase inhibitor. Ac-LETD-CHO has been reported to exert inhibitory effects on caspase 8[1] and on caspase 9.

Application

Caspase inhibitor Ac-LETD-CHO has been used to inhibit caspase-8.[1]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

LG0444

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells.

Jie Shi et al.

Biochemical pharmacology, 75(9), 1729-1742 (2008-04-02)

Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti-cancer function. I3M has been well established as a cyclin-dependent kinase (CDK) inhibitor, while the molecular mechanism underlying I3M-induced apoptosis has not been

Preventive Effects of Food Components on Caspase-8-Mediated Apoptosis Induced by Dietary Carcinogen, Trp-P-1, in Rat Mononuclear Cells

Hashimoto, T., et al.

ACS Symp. Ser., 851, 128-140 (2003)

Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways

Lara M

Scientific Reports (2017)

Apoptotic Regulation of Caspase Activity

Martinova, E.A., et al.

Russian J. Bioorg. Chem., 29, 471-495 (2003)

Caspase-9 takes part in programmed cell death in developing mouse kidney.

Takashi Araki et al.

Nephron. Experimental nephrology, 93(3), e117-e124 (2003-03-28)

Programmed cell death is a mechanism by which organisms dispose of unwanted cells, and it is thought to be an important process in organogenesis. We have already reported the role of caspase-3 in the developing metanephros. While caspase-3 is thought

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Caspase Inhibitor