MilliporeSigma
All Photos(1)

Documents

SCP0095

Sigma-Aldrich

Caspase Inhibitor

≥95% (HPLC)

All Photos(1)
Synonym(s):
Ac-LEHD-CHO, caspase 9 inhibitor
Empirical Formula (Hill Notation):
C23H34N6O9
Molecular Weight:
538.55
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Gene Information

human ... CASP9(842)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SCP0093SCP0094400011
Sigma-Aldrich

Sigma-Aldrich

SCP0095

Caspase Inhibitor

Sigma-Aldrich

Sigma-Aldrich

SCP0093

Caspase Inhibitor

Sigma-Aldrich

Sigma-Aldrich

SCP0094

Caspase Inhibitor

Sigma-Aldrich

Sigma-Aldrich

400011

Caspase-1 Inhibitor I, Cell-Permeable

form

lyophilized

form

lyophilized

form

lyophilized

form

solid

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

storage condition

OK to freeze

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... CASP9(842)

Gene Information

human ... CASP8(841), CASP9(842)

Gene Information

human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842)

Gene Information

-

composition

Peptide Content, ≥80%

composition

Peptide Content, ≥80%

composition

Peptide Content, ≥80%

composition

-

Amino Acid Sequence

Ac-Leu-Glu-His-Asp-al

Biochem/physiol Actions

Ac-Leu-Glu-His-Asp-al, or Ac-LEHD-CHO, is a cell-permeable tetrapeptide aldehyde. It is an inhibitor of caspase-9. Its target of action has been proposed to be the mitochondrial pathway of apoptosis. Ac-LEHD-CHO has also been postulated to prevent cleavage of caspase-8, and partly to prevent cleavage of caspase-3.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 3

1 of 3

N-Acetyl-Asp-Glu-Val-Asp-al ≥95%, powder

Sigma-Aldrich

A0835

N-Acetyl-Asp-Glu-Val-Asp-al

Z-Val-Ala-Asp fluoromethyl ketone powder, ≥90% (TLC)

Sigma-Aldrich

C2105

Z-Val-Ala-Asp fluoromethyl ketone

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone ≥90% (TLC), powder

Sigma-Aldrich

C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

Miyuki Tauchi et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Atherosclerotic lesions preferentially develop at bifurcations, characterized by non-uniform shear stress (SS). The aim of this study was to investigate SS-induced endothelial activation, focusing on stress-regulated mitogen-activated protein kinases (MAPK) and downstream signaling, and its relation to gap junction proteins
Daniel Purich
The Inhibitor Index: A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads (2017)
PP2A mediates apoptosis or autophagic cell death in multiple
myeloma cell lines
Hang Zhou
Oncotarget (2017)
Hang Zhou et al.
Oncotarget, 8(46), 80770-80789 (2017-11-09)
The crosstalk between apoptosis and autophagy contributes to tumorigenesis and cancer therapy. The process by which BetA (betulinic acid), a naturally occurring triterpenoid, regulates apoptosis and autophagy as a cancer therapy is unclear. In this study, we show for the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service