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SCP0095

Caspase Inhibitor

≥95% (HPLC)

Synonym(s):

Ac-LEHD-CHO, caspase 9 inhibitor

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5 MG

$316.00

$316.00

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About This Item

Empirical Formula (Hill Notation):
C23H34N6O9
Molecular Weight:
538.55
NACRES:
NA.32
UNSPSC Code:
12352200

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Product Name

Caspase Inhibitor, ≥95% (HPLC)

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Gene Information

human ... CASP9(842)

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This Item
SCP0093627610SCP0094
Caspase Inhibitor ≥95% (HPLC)

Sigma-Aldrich

SCP0095

Caspase Inhibitor

Caspase Inhibitor ≥95% (HPLC)

Sigma-Aldrich

SCP0093

Caspase Inhibitor

Caspase Inhibitor I Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.

Sigma-Aldrich

627610

Caspase Inhibitor I

Caspase Inhibitor

Sigma-Aldrich

SCP0094

Caspase Inhibitor

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

assay

≥95% (HPLC)

Gene Information

human ... CASP9(842)

Gene Information

human ... CASP8(841), CASP9(842)

Gene Information

-

Gene Information

human ... CASP10(843), CASP6(839), CASP8(841), CASP9(842)

form

lyophilized

form

lyophilized

form

solid

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

protect from light

storage condition

OK to freeze, desiccated

storage condition

protect from light

composition

Peptide Content, ≥80%

composition

Peptide Content, ≥80%

composition

-

composition

Peptide Content, ≥80%

Biochem/physiol Actions

Ac-Leu-Glu-His-Asp-al, or Ac-LEHD-CHO, is a cell-permeable tetrapeptide aldehyde. It is an inhibitor of caspase-9.[1][2] Its target of action has been proposed to be the mitochondrial pathway of apoptosis. Ac-LEHD-CHO has also been postulated to prevent cleavage of caspase-8, and partly to prevent cleavage of caspase-3.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
E1191
LN0886

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PP2A mediates apoptosis or autophagic cell death in multiple
myeloma cell lines
Hang Zhou
Oncotarget (2017)
Daniel Purich
The Inhibitor Index: A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads (2017)
Miyuki Tauchi et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Atherosclerotic lesions preferentially develop at bifurcations, characterized by non-uniform shear stress (SS). The aim of this study was to investigate SS-induced endothelial activation, focusing on stress-regulated mitogen-activated protein kinases (MAPK) and downstream signaling, and its relation to gap junction proteins
Hang Zhou et al.
Oncotarget, 8(46), 80770-80789 (2017-11-09)
The crosstalk between apoptosis and autophagy contributes to tumorigenesis and cancer therapy. The process by which BetA (betulinic acid), a naturally occurring triterpenoid, regulates apoptosis and autophagy as a cancer therapy is unclear. In this study, we show for the

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