14-455

Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg

Name: Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg
Brand: MM
Price: 3010 USD

Reagent (Ral GDS-RBD, agarose). A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD), for use in Affinity Binding Assays.

Synonym(s):

Ral GDS-RBD Assay Reagent, Rap1 Detection Reagent

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650 μG

$3,010.00

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About This Item

UNSPSC Code:

12352204

eCl@ss:

32160405

NACRES:

NA.41

Key Documents

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biological source

human

Quality Level

100

form

liquid

manufacturer/tradename

Upstate^®

technique(s)

affinity binding assay: suitable

NCBI accession no.

NM_018975.2

UniProt accession no.

Q9NYB0

shipped in

dry ice

Gene Information

human ... TERF2IP(54386)

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This Item	14-383	14-278	14-415
Sigma-Aldrich 14-455 Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg	Sigma-Aldrich 14-383 Rho Assay Reagent (Rhotekin RBD, agarose), 650 µg	Sigma-Aldrich 14-278 Ras Assay Reagent (Raf-1 RBD, agarose)	Sigma-Aldrich 14-415 Ral Assay Reagent (Ral BP1, agarose)
technique(s) affinity binding assay: suitable	technique(s) affinity binding assay: suitable	technique(s) activity assay: suitable	technique(s) affinity binding assay: suitable
biological source human	biological source mouse	biological source human	biological source -
form liquid	form -	form liquid	form liquid
Gene Information human ... TERF2IP(54386)	Gene Information mouse ... RTKN(20166)	Gene Information human ... MRAS(22808)	Gene Information -
UniProt accession no. Q9NYB0	UniProt accession no. Q9BST9	UniProt accession no. O14807	UniProt accession no. Q15311
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice

General description

A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD)

Product Source: expressed in E. coli

Preparation Note

6 months at -20C

Analysis Note

routinely evaluated by immunoblot analysis

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Amlodipine potentiates metalloproteinase activity and accelerates elastin degradation in a model of aneurysmal disease.

J R Boyle,I M Loftus,S Goodall,M Crowther,P R Bell,M M Thompson

European Journal of Vascular and Endovascular Surgery null

Rapid Ca2+-mediated activation of Rap1 in human platelets.

B Franke et al.

The EMBO journal, 16(2), 252-259 (1997-01-15)

Rap1 is a small, Ras-like GTPase whose function and regulation are still largely unknown. We have developed a novel assay to monitor the active, GTP-bound form of Rap1 based on the differential affinity of Rap1GTP and Rap1GDP for the Rap

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.

J F Rebhun et al.

The Journal of biological chemistry, 275(45), 34901-34908 (2000-08-10)

Although the Ras subfamily of GTPases consists of approximately 20 members, only a limited number of guanine nucleotide exchange factors (GEFs) that couple extracellular stimuli to Ras protein activation have been identified. Furthermore, no novel downstream effectors have been identified

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

Herrmann, C, et al

The Journal of Biological Chemistry, 271, 6794-6800 (1996)

Measurement of GTP-bound Ras-like GTPases by activation-specific probes.

M van Triest et al.

Methods in enzymology, 333, 343-348 (2001-06-13)

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