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MilliporeSigma

02487

Supelco

Chloroform

analytical standard

Synonym(s):

Methylidyne trichloride, Trichloromethane

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5 ML
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Estimated to ship onNovember 10, 2025Details

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
Beilstein/REAXYS Number:
1731042
EC Number:
200-663-8
MDL number:
MFCD00000826
UNSPSC Code:
12191502
PubChem Substance ID:
329747448
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

vapor density

4.1 (vs air)

vapor pressure

160 mmHg ( 20 °C)

assay

≥99.9% (GC)

shelf life

limited shelf life, expiry date on the label

contains

~0.003% amylene as stabilizer

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.444-1.447
n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

density

1.492 g/mL at 25 °C (lit.)

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

SMILES string

ClC(Cl)Cl

InChI

1S/CHCl3/c2-1(3)4/h1H

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

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1 of 4

This Item
PHR1552480150319988
Chloroform analytical standard

Supelco

02487

Chloroform

Chloroform Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1552

Chloroform

Chloroform ACS reagent, ≥99.8%, contains amylenes as stabilizer

Sigma-Aldrich

480150

Chloroform

Chloroform contains ethanol as stabilizer, ACS reagent, ≥99.8%

Sigma-Aldrich

319988

Chloroform

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

grade

ACS reagent

grade

ACS reagent

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

format

neat

format

neat

format

-

format

-

assay

≥99.9% (GC)

assay

-

assay

≥99.8%

assay

≥99.8%

vapor density

4.1 (vs air)

vapor density

4.1 (vs air)

vapor density

4.1 (vs air)

vapor density

4.1 (vs air)

General description

Chloroform is a colorless, volatile, liquid derivative of trichloromethane with an ether-like odor. It is a commonly used laboratory solvent. Presently, it is used in the industry as a solvent and in the production of the refrigerant freon. It is majorly used in production of chlorodifluoromethane, which is a refrigerant and fluoropolymer feedstock. It degrades in air to produce phosgene, dichloromethane, formyl chloride, CO, CO2 and hydrogen chloride. It can be orally consumed or inhaled, as it can be quickly absorbed, metabolized and eliminated by mammals.[1]

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

ppe

Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7801
BCCL8505
BCCH3995
BCCD9019
BCCB9592

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Chloroform
Watts, Peter.
World Health Organization Technical Report Series, October 08 (2004)
Radovan Spurny et al.
The Journal of biological chemistry, 288(12), 8355-8364 (2013-02-01)
Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, γ-aminobutyric acid GABA(A/C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that contain multiple allosteric binding sites for a variety of therapeutics, including general anesthetics. Here, we
Kuan Sun et al.
Nature communications, 6, 6013-6013 (2015-01-15)
Solution-processed organic photovoltaic cells (OPVs) hold great promise to enable roll-to-roll printing of environmentally friendly, mechanically flexible and cost-effective photovoltaic devices. Nevertheless, many high-performing systems show best power conversion efficiencies (PCEs) with a thin active layer (thickness is ~100 nm) that
Juyao Dong et al.
ACS nano, 8(5), 5199-5207 (2014-05-02)
The temperature increase inside mesoporous silica nanoparticles induced by encapsulated smaller superparamagnetic nanocrystals in an oscillating magnetic field is measured using a crystalline optical nanothermometer. The detection mechanism is based on the temperature-dependent intensity ratio of two luminescence bands in
Shuiquan Tang et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1616), 20120318-20120318 (2013-03-13)
Two novel reductive dehalogenases (RDases) that are highly similar to each other but catalyse distinct dechlorination reactions were identified from Dehalobacter-containing mixed cultures. These two RDases were partially purified from crude protein extracts of anaerobic dechlorinating enrichment cultures using blue
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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