02487

Chloroform

analytical standard

• Synonym(s): Methylidyne trichloride, Trichloromethane
• Empirical Formula (Hill Notation): CHCl₃
• CAS Number: 67-66-3
• Molecular Weight: 119.38
• Beilstein/REAXYS Number: 1731042
• EC Number: 200-663-8
• MDL number: MFCD00000826
• UNSPSC Code: 12191502
• PubChem Substance ID: 329747448
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• vapor density: 4.1 (vs air)
• vapor pressure: 160 mmHg ( 20 °C)
• assay: ≥99.9% (GC)
• shelf life: limited shelf life, expiry date on the label
• contains: ~0.003% amylene as stabilizer
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.444-1.447; n20/D 1.445 (lit.)
• bp: 60.5-61.5 °C (lit.)
• mp: −63 °C (lit.)
• density: 1.492 g/mL at 25 °C (lit.)
• application(s): agriculture; cleaning products; cosmetics; environmental; food and beverages; personal care
• format: neat
• SMILES string: ClC(Cl)Cl
• InChI: 1S/CHCl3/c2-1(3)4/h1H
• InChI key: HEDRZPFGACZZDS-UHFFFAOYSA-N

Description

General description

Chloroform is a colorless, volatile, liquid derivative of trichloromethane with an ether-like odor. It is a commonly used laboratory solvent. Presently, it is used in the industry as a solvent and in the production of the refrigerant freon. It is majorly used in production of chlorodifluoromethane, which is a refrigerant and fluoropolymer feedstock. It degrades in air to produce phosgene, dichloromethane, formyl chloride, CO, CO2 and hydrogen chloride. It can be orally consumed or inhaled, as it can be quickly absorbed, metabolized and eliminated by mammals.

Application

• Chloroform for organic synthesis: Chloroform is widely used in organic synthesis, providing a reliable solvent for the creation and purification of chemical compounds. It facilitates various reactions, including the integration of lipid analysis using advanced chromatographic techniques (Panczel et al., 2024).


• Chloroform as a catalyst in organic synthesis: Employed as a catalyst, chloroform enhances the catalytic efficiencies of various biochemical reactions, such as the activation methods in catalytic studies, aiding in the development of more efficient and sustainable chemical processes (Behera et al., 2024).

Recommended products

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Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• pcodes: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• target_organs: Central nervous system, Liver,Kidney
• wgk_germany: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash
• ppe: Eyeshields, Faceshields, Gloves