MilliporeSigma
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19215

Supelco

Butyric acid

analytical standard

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Linear Formula:
CH3CH2CH2COOH
CAS Number:
Molecular Weight:
88.11
Beilstein:
906770
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

vapor density

3.04 (vs air)

vapor pressure

0.43 mmHg ( 20 °C)

Assay

≥99.5% (GC)

autoignition temp.

824 °F

shelf life

limited shelf life, expiry date on the label

expl. lim.

10 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.398 (lit.)

bp

162 °C (lit.)

mp

−6-−3 °C (lit.)

density

0.964 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

SMILES string

CCCC(O)=O

InChI

1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)

InChI key

FERIUCNNQQJTOY-UHFFFAOYSA-N

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1 of 4

This Item
498932163962230
Butyric acid analytical standard

Supelco

19215

Butyric acid

Succinic acid certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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49893

Succinic acid

Octanoic acid analytical standard

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Octanoic acid

Linoleic acid analytical standard

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62230

Linoleic acid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

format

neat

format

neat

format

neat

vapor density

3.04 (vs air)

vapor density

-

vapor density

5 (vs air)

vapor density

-

vapor pressure

0.43 mmHg ( 20 °C)

vapor pressure

-

vapor pressure

1 mmHg ( 78 °C)

vapor pressure

-

General description

Butyric acid is a four-carbon containing, saturated short-chain fatty acid. It commonly occurs in its ester form in animal-based fats and plant-based oils. It is a potent differentiation agent for cells and also possesses antiproliferative activity. In cultured mammalian cells, it affects growth rate, morphology, and gene expression. It also induces apoptosis.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Application

This analytical standard can also be used as follows:

  • Development and validation of a high-performance liquid chromatographic (HPLC) method combined with UV detection to determine four short-chain fatty acids— formic acid, acetic acid, propionic acid, and butyric acid, and lactic acid in bacterial culture samples after their liquid-liquid extraction (LLE)
  • Simultaneous analysis of 10 volatile and non-volatile organic acids in 18 samples of Korean traditional fermented soybean paste, doenjang, by HPLC combined with refractive index detector and gas chromatography coupled with flame ionization detector (GC-FID)
  • Determination of butyric, lactic, acetic, and propionic acids in sour cassava starch waste-water samples by reversed-phase high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE), both coupled with diode array detection (DAD)
  • Multi-residue analysis of six short-chain fatty acids— acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid, in biological samples of mice colon content by a gas chromatographic method combined with flame ionization detector (GC-FID)
  • Packed-fiber solid phase extraction (PFSPE) of eight short-chain fatty acids using polypyrrole nanofibers, from urine samples of children for quantification by gas chromatography-mass spectrometry (GC-MS)
  • Multi-residue analysis of 76 volatile compounds from jujube extract samples by gas chromatography-mass spectrometry (GC-MS) after their extraction by steam distillation combined with drop-by-drop extraction

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

161.6 °F - closed cup

Flash Point(C)

72 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

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2-Ethylbutyric acid 99%

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H M Chen et al.
Clinical chemistry, 35(1), 74-76 (1989-01-01)
We describe a procedure for preparing fecal samples for determination of volatile fatty acids (VFAs) by gas-liquid chromatography (GLC) and "high-performance" liquid chromatography (HPLC). The simple, one-step procedure involves only ultrafiltration through a membrane with a molecular-mass cutoff of 3000
Butyric acid: a small fatty acid with diverse biological functions.
K N Prasad
Life sciences, 27(15), 1351-1358 (1980-10-13)
Amita Patnaik et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 8(7), 2142-2148 (2002-07-13)
Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), has demonstrated greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA in preclinical
Livia H Morais et al.
Current biology : CB, 30(19), 3761-3774 (2020-08-22)
Birth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders. Moreover, alterations of the microbiome have been shown to affect neurodevelopmental trajectories. However, the long-term effects of C-section
Gili Berkovitch et al.
Journal of medicinal chemistry, 51(23), 7356-7369 (2008-11-15)
Multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid in cancer cell lines inhibited the proteasome and induced apoptosis and heme synthesis. The most potent prodrug was butyryloxymethyl 5-amino-4-oxopentanoate (1a). The metabolically released formaldehyde from the prodrugs was the dominant factor affecting

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