In solution, this material does not require handling in a fume hood. As a general practice, gloves and eye protection are recommended. This product is not considered to be a hazardous material. Please review the Product Safety Data Sheet at the link below:
https://www.sigmaaldrich.com/sds/sigma/a2661?userType=red
A2661
Acetylcholine chloride
suitable for cell culture
Synonym(s):
ACh
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25 G
$89.20
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$288.00
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About This Item
Linear Formula:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS Number:
Molecular Weight:
181.66
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
32190102
UNSPSC Code:
12352209
EC Number:
200-468-8
MDL number:
Beilstein/REAXYS Number:
3571875
Biological source:
synthetic
Form:
powder
Assay:
~99%
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Product Name
Acetylcholine chloride, suitable for cell culture
InChI key
JUGOREOARAHOCO-UHFFFAOYSA-M
InChI
1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
SMILES string
[Cl-].CC(=O)OCC[N+](C)(C)C
biological source
synthetic
assay
~99%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
146-150 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... CHRM3(1131)
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1 of 4
This Item | PHR1546 | A9101 | Y0000002 |
|---|---|---|---|
| biological source synthetic | biological source - | biological source - | biological source - |
| assay ~99% | assay - | assay ≥99% (TLC) | assay - |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level - |
| form powder | form - | form powder or crystals | form - |
| technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - |
| Gene Information human ... CHRM3(1131) | Gene Information human ... CHRM3(1131) | Gene Information human ... CHRM3(1131) | Gene Information human ... CHRM3(1131) |
Application
Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh).[1] It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).[2]
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing
Sletten D M, et al.
Autonomic Neuroscience : Basic & Clinical, 150(1-2), 127-130 (2009)
Yue-Chen Chang et al.
Kidney & blood pressure research, 43(5), 1607-1622 (2018-10-23)
This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in the rat interlobar artery occurs through altered expression of the gap junction protein connexin 43 (Cx43). This study randomly divided male Sprague
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates
Garavaglia A, et al.
BMC Neuroscience, 11(1), 7-7 (2010)
Fabian Hertel et al.
ACS chemical biology, 15(1), 33-38 (2019-12-20)
Phosphoinositides constitute a critical family of lipids that regulate numerous cellular processes. Phosphatidylinositol 4,5-bisphosphate (PIP2) is arguably the most important plasma membrane phosphoinositide and is involved in regulating diverse processes. It is also the precursor of phosphatidylinositol 3,4,5-trisphosphate (PIP3), which
Wei Shi et al.
The Journal of biological chemistry, 295(22), 7653-7668 (2020-04-24)
The erythropoietin-producing human hepatocellular receptor EPH receptor B6 (EPHB6) is a receptor tyrosine kinase that has been shown previously to control catecholamine synthesis in the adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent fashion. EPHB6 also has a role in
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Hi, is the reconstituted product safe to be used without any special precautions under a biological hood?
1 answer-
Helpful?
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Hello, I would like to ask the difference between Acetylcholine A6625 vs A2661. I am planinig to use in cardiovascular research. Could I learn the exact difference between them? Thank you
1 answer-
Product A2661 is tested for the suitability of cell culture applications. Please see the product specification sheet to view the testing done on this product:
https://www.sigmaaldrich.com/specification-sheet/SIGMA/A2661Product A6625 is not tested for the suitability of cell culture applications. Please see the specification sheet to view the testing done on this product:
https://www.sigmaaldrich.com/specification-sheet/SIGMA/A6625Helpful?
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How should a solution of Acetylcholine chloride be stored?
1 answer-
The reconstituted solution is stable for 2 weeks when stored at 2-8°C.
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