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F3917

Sigma-Aldrich

Forskolin

For use in molecular biology applications

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Synonym(s):
7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin
Empirical Formula (Hill Notation):
C22H34O7
CAS Number:
Molecular Weight:
410.50
Beilstein:
1692716
EC Number:
MDL number:
PubChem Substance ID:

biological source

Coleus forskohlii

description

for activation of T cells

product line

BioReagent

Assay

≥98% (HPLC)

form

powder

mol wt

410.50  g/mol

color

white to off-white

solubility

ethanol: soluble

suitability

suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells

storage temp.

room temp

SMILES string

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

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This Item
F6886D3658PHL89664
Forskolin For use in molecular biology applications

Sigma-Aldrich

F3917

Forskolin

Forskolin from Coleus forskohlii, ≥98% (HPLC), powder

Sigma-Aldrich

F6886

Forskolin

Forskolin phyproof® Reference Substance

PHL89664

Forskolin

form

powder

form

powder

form

solid

form

crystals

mol wt

410.50  g/mol

mol wt

-

mol wt

-

mol wt

-

color

white to off-white

color

white to off-white

color

white to off-white

color

-

solubility

ethanol: soluble

solubility

ethanol: soluble 50 mg/mL

solubility

methanol: 28 mg/mL(lit.), DMSO: 3 mg/mL(lit.), chloroform: 50 mg/mL, ethanol: 6.6 mg/mL(lit.), dilute aqueous acid and base: insoluble(lit.)

solubility

-

storage temp.

room temp

storage temp.

-

storage temp.

−20°C

storage temp.

-

General description

Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii.

Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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