M1559

Moxonidine hydrochloride

Name: Moxonidine hydrochloride
Brand: SIGMA
Price: 135 USD
Availability: InStock

≥98%

Synonym(s):

4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride, BDF-5895

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂ClN₅O · HCl

CAS Number:

75438-58-3

Molecular Weight:

278.14

NACRES:

NA.77

PubChem Substance ID:

24278537

UNSPSC Code:

12352200

MDL number:

MFCD06795643

Key Documents

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Product Name

Moxonidine hydrochloride, ≥98%

InChI

1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H

SMILES string

Cl.COc1nc(C)nc(Cl)c1NC2=NCCN2

InChI key

ZZPAWQYZQVUVHX-UHFFFAOYSA-N

assay

≥98%

originator

Solvay

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1 of 4

This Item	E3263	T6950	R9525
Sigma-Aldrich M1559 Moxonidine hydrochloride	Sigma-Aldrich E3263 Efaroxan hydrochloride	Sigma-Aldrich T6950 Tizanidine hydrochloride	Sigma-Aldrich R9525 RX 821002 hydrochloride
assay ≥98%	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
originator Solvay	originator -	originator Acorda Therapeutics	originator -
Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), NISCH(11188)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)	Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Application

Moxonidine hydrochloride has been used:

as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method[1]
as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC)[2]
as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN)[3]

Biochem/physiol Actions

Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently.[4] Moxonidine also exhibits spinal analgesic activity through the α_2C-adrenoceptor component.[5]

Features and Benefits

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Solvay. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Prediction of blood-brain barrier permeation of α-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis.

Jelica Vucicevic et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 68, 94-105 (2014-12-30)

Imidazoline receptor ligands are a numerous family of biologically active compounds known to produce central hypotensive effect by interaction with both α2-adrenoreceptors (α2-AR) and imidazoline receptors (IRs). Recent hypotheses connect those ligands with several neurological disorders. Therefore some IRs ligands

Estimation of lipophilicity and retention behavior of some alpha adrenergic and imidazoline receptor ligands using RP-TLC

Mohamed S, et al.

Journal of Liquid Chromatography and Related Technologies, 37(20), 2829-2845 (2014)

Moxonidine inhibits excitatory inputs to airway vagal preganglionic neurons via activation of both α2-adrenoceptors and imidazoline I1 receptors.

Xujiao Zhou et al.

Brain research, 1732, 146695-146695 (2020-02-03)

As an imidazoline I1 receptor agonist with very weak binding affinity for α2-adrenoceptors, moxonidine is commonly used in the treatment of hypertension. Moxonidine also has been implicated to act centrally to reduce airway vagal outflow. However, it is unknown at

Moxonidine: a new and versatile antihypertensive.

F Messerli

Journal of cardiovascular pharmacology, 35(7 Suppl 4), S53-S56 (2001-05-11)

Despite a proven efficacy in lowering blood pressure, centrally acting antihypertensive drugs are no longer widely used because of the relative high incidence of adverse effects. Most central side-effects occurring with these drugs are mediated by the alpha2-receptor. Moxonidine is

Moxonidine: a review of its use in essential hypertension.

Caroline Fenton et al.

Drugs, 66(4), 477-496 (2006-04-07)

Moxonidine (Physiotens, Moxon, Cynt) is an orally administered imidazoline compound with selective agonist activity at imidazoline I1 receptors and only minor activity at alpha2-adrenoceptors. Moxonidine acts centrally to reduce peripheral sympathetic activity, thus decreasing peripheral vascular resistance. In patients with

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Moxonidine hydrochloride