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Merck

A5000

Acetaminofeno

meets USP testing specifications, 98.0-102.0%, powder

Sinônimo(s):

4′-Hidroxiacetanilida, 4-Acetamidofenol, N-(4-Hidroxifenil)acetamida, N-Acetil-4-aminofenol, APAP, Paracetamol

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Sobre este item

Fórmula linear:
CH3CONHC6H4OH
Número CAS:
103-90-2
Peso molecular:
151.16
UNSPSC Code:
12352111
NACRES:
NA.25
PubChem Substance ID:
24890930
MDL number:
MFCD00002328
Beilstein/REAXYS Number:
2208089

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Nome do produto

Acetaminofeno, meets USP testing specifications, 98.0-102.0%, powder

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

SMILES string

CC(=O)Nc1ccc(O)cc1

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

agency

USP/NF
meets USP testing specifications

assay

98.0-102.0%

form

powder

mp

168-172 °C (lit.)

solubility

DMSO: 5 M
ethanol: 50 mg/mL
H2O: very slightly soluble

application(s)

pharmaceutical (small molecule)

Quality Level

200

Gene Information

human ... FAAH(2166), PTGS1(5742), PTGS2(5743), TRPV1(7442)

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1 of 4

Este Item
PHR1005A-064Y0001781
Acetaminofeno meets USP testing specifications, 98.0-102.0%, powder

Sigma-Aldrich

A5000

Acetaminofeno

Acetaminofeno Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1005

Acetaminofeno

Acetaminophen solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

A-064

Acetaminophen solution

Acetaminofeno European Pharmacopoeia (EP) Reference Standard

Y0001781

Acetaminofeno

assay

98.0-102.0%

assay

-

assay

-

assay

-

form

powder

form

-

form

liquid

form

-

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

-

solubility

DMSO: 5 M, H2O: very slightly soluble, ethanol: 50 mg/mL

solubility

-

solubility

-

solubility

-

agency

USP/NF

agency

traceable to BP 371, traceable to Ph. Eur. P030000, traceable to USP 1003009

agency

-

agency

-

mp

168-172 °C (lit.)

mp

168-172 °C (lit.)

mp

-

mp

168-172 °C (lit.)

Application

Analgésico.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de armazenamento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

364.3 °F - Pensky-Martens closed cup

flash_point_c

184.6 °C - Pensky-Martens closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
MKCX1247
MKCV4785
MKCT8276
MKCT3819
MKCS3304

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Mohammad A Rahman et al.
Scientific reports, 9(1), 6571-6571 (2019-04-27)
Cellular CYP2E1 is well-known to mediate alcohol- (ALC) and acetaminophen- (APAP) induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining importance in understanding mechanism of intra- and inter-cellular communication, the functional role of drug metabolizing cytochrome P450
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Could we know the approximate size range of the acetaminophen (Product number: A5000) powder particles?

    1 answer

    1. This product is not tested for particle size. The material is sieved and the majority of particles fall through a 100-mesh sieve, indicating the bulk is smaller than 150 microns.

      Helpful?

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