Solutions prepared in DMSO at 50 mg/mL may be stored in working aliquots at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles.
92131
Trimetropima
≥99.0% (HPLC)
Sinônimo(s):
2,4-Diamino-5-(3,4,5-trimetoxibenzil)pirimidina, NSC 106568
Faça login para ver os preços organizacionais e de contrato.
Selecione um tamanho
1 G
R$ 494,00
5 G
R$ 1.561,00
25 G
R$ 6.758,00
Sobre este item
Fórmula empírica (Notação de Hill):
C14H18N4O3
Número CAS:
Peso molecular:
290.32
UNSPSC Code:
51285203
NACRES:
NA.85
PubChem Substance ID:
EC Number:
212-006-2
Beilstein/REAXYS Number:
625127
MDL number:
Pular para
Assistência Técnica
Precisa de ajuda? Nossa equipe de cientistas experientes está à sua disposição.
Estamos aqui para ajudarNome do produto
Trimetropima, ≥99.0% (HPLC)
InChI key
IEDVJHCEMCRBQM-UHFFFAOYSA-N
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
SMILES string
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
biological source
synthetic
assay
≥99.0% (HPLC)
form
powder
color
white to light yellow
mp
≥199.0 °C
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
Quality Level
Gene Information
human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)
Procurando produtos similares? Visita Guia de comparação de produtos
Categorias relacionadas
1 of 4
Este Item | T7883 | T2200000 | 46984 |
|---|---|---|---|
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action DNA synthesis | interferes, enzyme | inhibits |
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria | antibiotic activity spectrum - | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 100 |
| form powder | form powder | form - | form - |
| assay ≥99.0% (HPLC) | assay ≥98.5% | assay - | assay - |
| biological source synthetic | biological source - | biological source - | biological source - |
Application
Usada principalmente como agente antibacteriano. Inibidora da di-hidrofolato redutase com seletividade para a enzima de procariotos.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
General description
Chemical structure: pyrimidine
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.
Packaging
1g,5g,25g
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Classe de armazenamento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
R de Groot et al.
Antimicrobial agents and chemotherapy, 32(4), 477-484 (1988-04-01)
We studied 10 trimethoprim-resistant (Tmpr) Haemophilus influenzae isolates for which agar dilution MICs were 10 to greater than 200 micrograms/ml. Trimethoprim resistance was transferred from two Tmpr H. influenzae isolates to a Tmps strain by conjugation or transformation. Wild-type Tmpr
Susceptibility of Mycobacterium tuberculosis to sulfamethoxazole, trimethoprim and their combination over a 12 year period in Taiwan.
Tsi-Shu Huang1,2,3, Calvin M. Kunin, et al.
The Journal of Antimicrobial Chemotherapy, 10, 633-637 (2011)
Kate S Baker et al.
The Lancet. Infectious diseases, 15(8), 913-921 (2015-05-06)
Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who
Karin Tegmark Wisell et al.
The Journal of antimicrobial chemotherapy, 62(1), 35-40 (2008-04-15)
The lack of oral treatment alternatives for enterococcal urinary tract infections (UTIs) has led to a renewed interest in trimethoprim. Enterococci can incorporate exogenously produced folates and thereby reverse the effect of trimethoprim. Although a large proportion of enterococci appear
O Sköld
Veterinary research, 32(3-4), 261-273 (2001-07-04)
Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing
Artigos
Cancer research innovations address the complexity of the disease, providing advanced technologies for varied applications.
Biofiles reviews innovative technologies for cancer research, reflecting the complexity of the disease.
-
Upon dilution in DMSO, what is the best storage condition for trimethoprim (fridge/freezer, how long is it stable for)?
1 answer-
Helpful?
-
-
Is Trimethoprim soluble in DMSO or water?
1 answer-
The solubility of this product is not analyzed on a lot-to-lot basis. The compound is expected to be soluble in water at 0.4 mg/ml, ethanol at 2.6 mg/ml, methanol at 12.1 mg/ml, chloroform at 22.2 mg/ml, and DMSO at 50 mg/ml.
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
Is Trimethoprim stable in solution?
1 answer-
Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
Helpful?
-
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica