439134

Sigma-Aldrich

Acetonitrile

suitable for HPLC, gradient grade, ≥99.9%

Synonym(s):
Cyanomethane, Methyl cyanide, ACN, Ethyl nitrile
Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein/REAXYS Number:
741857
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.03

grade

gradient grade

Quality Level

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

973 °F

purified by

sub-micron filtration

expl. lim.

16 %

HPLC gradient analysis

≤0.5 mAU (@254 nm)
≤3 mAU, @ 210 nm

baseline drift at 210 nm

≤15 mAU

application(s)

HPLC: suitable
UV/Vis spectroscopy: suitable

impurities

≤0.0002% free alkali (as NH3)
≤0.001% free acid (as CH3COOH)
≤0.01% water (Karl Fischer)
≤0.5 ppb quinine fluor., 365 nm
≤1 ppb quinine fluor., 254 nm

evapn. residue

<0.0002%

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

solubility

water: soluble

density

0.786 g/mL at 25 °C (lit.)

λ

H2O reference

UV absorption

λ: 195 nm Amax: ≤0.12
λ: 200 nm Amax: ≤0.032
λ: 230 nm Amax: ≤0.0044

Featured Industry

Food and Beverages

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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General description

Acetonitrile (MeCN), an aliphatic nitrile, is a colorless liquid with a pleasant odor. It is widely used as a solvent and intermediate in organic syntheses. It is transparent to UV-visible light making it highly applicable in spectrophotometric and fluorimetric techniques. As MeCN has low viscosity, high elution strength and is highly miscible in water, it is utilized as a mobile phase component in many chromatographic techniques. Its infrared spectrum has been recorded. Synthesis of alkyl hydroperoxides in MeCN by alkane oxidation with hydrogen peroxide in the presence of iron complexes has been studied. The hydrogenation of MeCN to form ethylamine using Co–B amorphous alloy catalyst has been investigated.

Packaging

1, 4, 4×4 L in PVC-coated bottle
20 L in Nowpak™
2×10 L in Nowpak™
20 L in Nowpak™ II
18 L in VerSA-Flow™

Preparation Note

Product filtered through a 0.2 μm filter

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Pictograms

FlameExclamation mark

Signal Word

Danger

RIDADR

UN 1648 3 / PGII

WGK Germany

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

H Haugen et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 73(2), 229-237 (2005-03-10)
This article deals with enzyme-induced biodegradation behavior of thermoplastic polyether-urethane (TPU). Porous scaffolds were processed by a new foaming method applied in hot pressing and injection molding. The scaffolds were subsequently gamma sterilized. The samples were incubated with cholesterol esterase...
Liquid phase hydrogenation of acetonitrile to ethylamine over the Co-B amorphous alloy catalyst.
Li H, et al.
J. Catal., 214(1), 15-25 (2003)
Hydrogen peroxide oxygenation of alkanes including methane and ethane catalyzed by iron complexes in acetonitrile.
Shul'pin GB, et al.
Advanced Synthesis & Catalysis, 346(2-3), 317-332 (2004)
Infrared spectra of acetonitrile and acetonitrile-d3.
Pace EL and Noe LJ.
J. Chem. Phys. , 49, 5317-5325 (1968)
Eagleson M.
Concise Encyclopedia Chemistry, 6-6 (1994)

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