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52423

Dextran sulfate sodium salt from Leuconostoc spp.

low sulfate content, Mr ~40,000

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About This Item

CAS Number:
9011-18-1
MDL number:
MFCD00081551
UNSPSC Code:
12352201
NACRES:
NA.25

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biological source

(Leuconostoc spp)

form

powder

quality

low sulfate content

mol wt

Mr ~40,000

composition

Sulfur Content, 8-13%

loss

≤10% loss on drying

color

white to off-white

useful pH range

6.0-8 (10 g/L)

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

storage temp.

room temp

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This Item
D6001D8906D6924
Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content, Mr ~40,000

Sigma-Aldrich

52423

Dextran sulfate sodium salt from Leuconostoc spp.

Dextran sulfate sodium salt from Leuconostoc spp. average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8

Sigma-Aldrich

D6001

Dextran sulfate sodium salt from Leuconostoc spp.

Dextran sulfate sodium salt from Leuconostoc spp. Molecular Biology, average Mw >500,000 (dextran starting material), contains 0.5-2% phosphate buffer

Sigma-Aldrich

D8906

Dextran sulfate sodium salt from Leuconostoc spp.

Dextran sulfate sodium salt from Leuconostoc spp. average mol wt 9,000-20,000

Sigma-Aldrich

D6924

Dextran sulfate sodium salt from Leuconostoc spp.

biological source

(Leuconostoc spp)

biological source

bacterial (Leuconostoc mesenteroides)

biological source

synthetic

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

100

Quality Level

200

Quality Level

300

Quality Level

200

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

room temp

useful pH range

6.0-8 (10 g/L)

useful pH range

6.0-8.0 (1% in water)

useful pH range

6.0-8 (10 g/L)

useful pH range

5.5 - 8.0

General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate increases binding of epithelial cells and lymphocytes to extracellular matrix proteins including fibronectin and laminin. In addition, dextran sulfate altered expreβion of cell surface receptors integrins. [1]
Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.

Preparation Note

Sigma dextrans are derived from Leuconostoc mesenteroides.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH7831
BCCD9375
BCCB2932
BCBW7043
BCBP6912V

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J Ni et al.
Gut, 39(2), 234-241 (1996-08-01)
The effects of dextran sulphate sodium (DSS) on mouse intestinal epithelial cells and intraepithelial lymphocytes were analysed to investigate the mechanism by which DSS induces colitis and tumours in mice. Cytotoxicity of DSS towards intestinal epithelial cells and intestinal intraepithelial
Jiang-Hua Liu et al.
Disease models & mechanisms, 13(11) (2020-10-10)
Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies showed that Akkermansia muciniphila, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this
Aaron H Rose et al.
Inflammatory bowel diseases, 21(9), 2005-2015 (2015-06-16)
An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and

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