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Merck

APP

amyloid beta (A4) precursor protein

同義詞:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
物種:
Human APP (351), Mouse App (11820), Rat App (54226), fruit fly app (39399), chicken APP (374198), dog APP (403407), domestic cat APP (101085564), cow APP (280722), sheep APP (101111593), domestic guinea pig App (100715302)
UniProtKB ID:
P05067, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438
基因 ID:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein

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ELISA

產品編號
描述
物種
EZHS40
High Sensitivity Human Amyloid β40 ELISA, ,
物種
human
EZHS42
High Sensitivity Human Amyloid β42 ELISA, ,
物種
human
EZBRAIN42
Human Amyloid β42 Brain ELISA, ,
物種
human
RAB0530
人APP /淀粉样蛋白A4蛋白ELISA试剂盒, for serum, plasma, cell culture supernatants and urine,
物種
human
EZBRAIN-SET
Human Amyloid β40 and Amyloid β42 Brain ELISA, ,
物種
human

Small Molecule - Antagonist

產品編號
描述
物種
B9934
BTA-1, ≥98% (HPLC), solid,
物種
human
C1386
姜黄素, from Curcuma longa (Turmeric), powder,
物種
human
C7727
姜黄素, ≥94% (curcuminoid content), ≥80% (Curcumin),
物種
human
F8514
氟比洛芬, cyclooxygenase inhibitor,
物種
human, rat

Antibodies

產品編號
描述
物種活性
應用
MAB348
抗APP A4抗体，a.a.APP{NT}的66-81，克隆22C11, clone 22C11, Chemicon®, from mouse,
物種活性
canine, fish, human, monkey, mouse, pig, rat
應用
immunofluorescence
immunohistochemistry
western blot
MABN10
抗-淀粉样蛋白β抗体，克隆W0-2, clone WO2, from mouse,
物種活性
human, mouse
應用
ELISA
immunohistochemistry
western blot
A5213
抗β-淀粉样抗体，小鼠单克隆 小鼠抗, clone BAM-10, ascites fluid,
物種活性
human
應用
ELISA
immunohistochemistry
AB5078P
抗β-淀粉样蛋白1-42抗体, Chemicon®, from rabbit,
物種活性
chicken, human, mouse
應用
ELISA
immunohistochemistry
western blot
AB9234
抗淀粉样蛋白寡聚体抗体，αβ，寡聚体, serum, Chemicon®,
物種活性
eukaryotes, human, mouse, rat
應用
ELISA
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot

Proteins

產品編號
描述
物種
A9810
淀粉样蛋白β蛋白片段1-42, ,
物種
human
A4559
β-淀粉样蛋白片段 25-35, ≥97% (HPLC),
物種
human
AG968
β 淀粉样蛋白 1-42, aβ, 超纯，HFIP，人重组, ,
物種
human
AG912
β 淀粉样蛋白 1-42, aβ, 超纯，TFA，重组人, ,
物種
human
A1075
淀粉样蛋白β蛋白片段1-40, ≥90% (HPLC), powder,
物種
human