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Oxymatrine

Name: Oxymatrine
Brand: SIGMA

About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₄N₂O₂

CAS Number:

16837-52-8

Molecular Weight:

264.36

NACRES:

NA.25

PubChem Substance ID:

329818891

UNSPSC Code:

12352200

MDL number:

MFCD00210339

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Properties

assay

≥98% (HPLC)

Quality Level

100

form

powder

solubility

methanol: 10 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

[O-][N+]12CCCC3CN4C(CCCC4=O)C(CCC1)C23

InChI

1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1

InChI key

XVPBINOPNYFXID-LHDUFFHYSA-N

Description

Biochem/physiol Actions

Alkaloid isolated from Sophora flavescens. Antifribotic. Neuroprotective. Traditional chinese medicine used in the treatment against hepatitis B virus.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution by high-performance liquid chromatography coupled with mass spectrometry.

Ruoxi Fan et al.

Fitoterapia, 89, 271-277 (2013-06-12)

A rapid, sensitive and selective high-performance liquid chromatography mass spectrometric method has been developed and validated for the simultaneous determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution. Analytes were extracted from

Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression.

Ying Zhang et al.

Biochemical pharmacology, 85(1), 59-68 (2012-10-30)

The human ether-a-go-go-related gene (hERG) encodes the rapidly activating, delayed rectifier potassium channel (IKr) important for cardiac repolarization. Dysfunction of the hERG channel can cause Long QT Syndrome (LQTS). A wide variety of structurally diverse therapeutic compounds reduce the hERG

Selective extraction and separation of oxymatrine from Sophora flavescens Ait. extract by silica-confined ionic liquid.

Wentao Bi et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 880(1), 108-113 (2011-12-06)

This study highlighted the application of a two-stepped extraction method for extraction and separation of oxymatrine from Sophora flavescens Ait. extract by utilizing silica-confined ionic liquids as sorbent. The optimized silica-confined ionic liquid was firstly mixed with plant extract to

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Global Trade Item Number

SKU	GTIN
O0891-10MG	04061832402000

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