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Merck

AR

androgen receptor

Sinônimos:
AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Espécies:
Human AR (367), Mouse Ar (11835), Rat Ar (24208), fruit fly ar (44503), Zebrafish ar (100005148), chicken AR (422165), dog AR (403588), domestic cat AR (101081787), domestic cat AR (751827), Horse AR (100033980) ...Mais
ID UniProtKB:
P10275, A2RUN2, B1AKD7, Q9UD95
ID do gene:
  • Human(367) Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(11835) androgen receptor
  • Rat(24208) androgen receptor
  • fruit fly(44503) abdomen rotatum
  • Zebrafish(100005148) androgen receptor
  • chicken(422165) androgen receptor
  • dog(403588) androgen receptor
  • domestic cat(101081787) androgen receptor
  • domestic cat(751827) androgen receptor
  • Horse(100033980) androgen receptor
  • cow(280675) androgen receptor
  • sheep(443042) androgen receptor
  • Goat(100860827) androgen receptor
  • Domestic Rabbit(100009193) androgen receptor
  • domestic guinea pig(100726891) androgen receptor

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Small Molecule - Activator

Número do produto
Descrição
Espécies
E8750
α-Estradiol, powder, ≥98% (TLC),
Espécies
human, rat
484431
Propylene glycol monomethyl ether acetate, ReagentPlus®, ≥99.5%,
Espécies
human
R5010
Resveratrol, ≥99% (HPLC),
Espécies
human, rat, mouse
D4628
Diethylstilbestrol, ≥99% (HPLC),
Espécies
human, mouse, rat
M1629
Medroxyprogesterone 17-acetate, ≥97% (HPLC),
Espécies
human, rat

Small Molecule - Agonist

Número do produto
Descrição
Espécies
N2260
D(−)-Norgestrel, analytical standard,
Espécies
human, rat
BP688
Cyproterone acetate, British Pharmacopoeia (BP) Reference Standard,
Espécies
human
C3283000
Cyproterone acetate, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
Y0001390
Cyproterone acetate for peak identification, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
C3412
Cyproterone acetate, ≥98%,
Espécies
human, mouse, rat

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
B9300
Benzophenone, ReagentPlus®, 99%,
Espécies
rat
V1104
Vanilina, ReagentPlus®, 99%,
Espécies
rat
P53357
Propil 4-hidroxibenzoato, ≥99%,
Espécies
rat
47889
Metil 4-hidroxibenzoato, PESTANAL®, analytical standard,
Espécies
rat
W310727
Vanilina, natural, ≥97%, FCC, FG,
Espécies
rat

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
SAB5500007
Anti-Androgen Receptor (C-term) antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP242, affinity isolated antibody,
Reatividade de espécies
dog, human, mouse, pig, rabbit, rat
Aplicação
immunohistochemistry
04-078
Anti-phospho-Androgen Receptor (Ser81) Antibody, rabbit monoclonal, culture supernatant, Upstate®,
Reatividade de espécies
human
Aplicação
western blot
SAB5500006
Anti-Androgen Receptor antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP107, affinity isolated antibody,
Reatividade de espécies
dog, human, mouse, pig, rat
Aplicação
immunohistochemistry
SAB5600067
Anti-AR (n-terminal) antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM254, purified immunoglobulin,
Reatividade de espécies
human
Aplicação
immunohistochemistry
western blot
WH0000367M1
Monoclonal Anti-AR antibody produced in mouse, clone 1G3, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
immunohistochemistry
proximity ligation assay
western blot

Small Molecule - Blocker

Número do produto
Descrição
Espécies
F9397
Flutamide, ,
Espécies
mouse, rat, human

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
136123
trans-Chalcone, 97%,
Espécies
rat, human
158348
4-(Benzyloxy)phenol, 98%,
Espécies
rat, human
SML1375
Galeterone, ≥98% (HPLC),
Espécies
human
S3378
Spironolactone, 97.0-103.0%,
Espécies
rat, human
C8667
Colesterol, Sigma Grade, ≥99%,
Espécies
rat, human

Small Molecule - Ligand

Número do produto
Descrição
Espécies
T5648
Tamoxifeno, ≥99%,
Espécies
human, rat
P8783
Progesterone, powder, BioReagent, suitable for cell culture,
Espécies
mouse, human, rat
P0130
Progesterone, ≥99%,
Espécies
mouse, human, rat
P3972
Progesterone, meets USP testing specifications,
Espécies
mouse, human, rat
P6149
Progesterone, γ-irradiated, BioXtra, suitable for cell culture,
Espécies
mouse, human, rat

Proteins

Número do produto
Descrição
Espécies
346101-M
Androgen Receptor, His•Tag®, Human, Recombinant, S. frugiperda, recombinant human, expressed in S. frugiperda,
Espécies
human
SRP2071
Androgen receptor (650-920), human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
EHU025951
MISSION® esiRNA, targeting human AR,
Espécies
human
EMU006201
MISSION® esiRNA, targeting mouse Ar,
Espécies
mouse