Key Documents

View All Documentation

Pindolol

Name: Pindolol
Brand: SIGMA
Price: 157 CAD

≥98% (TLC), β1-adrenoceptor antagonist, powder

Synonym(s):

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

Select a Size

Change View

Pack Size	SKU	Availability	Price
250 mg		Please contact Customer Service for Availability	$157.00
1 g		Check Cart for Availability	$188.00

About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₀N₂O₂

CAS Number:

13523-86-9

Molecular Weight:

248.32

NACRES:

NA.77

PubChem Substance ID:

24277795

UNSPSC Code:

12352200

EC Number:

236-867-9

MDL number:

MFCD00010530

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

$157.00

Please contact Customer Service for Availability

Request a Bulk Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Pindolol, ≥98% (TLC), powder

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

167-171 °C (lit.)

solubility

0.1 M NaOH: 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, acetic acid: 50 mg/mL, H₂O: insoluble

originator

Novartis

storage temp.

2-8°C

SMILES string

CC(C)NCC(O)COc1cccc2[nH]ccc12

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), HTR1A(3350)

Description

Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem/physiol Actions

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

Features and Benefits

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	P8688	SML1913	P0884
Sigma-Aldrich P0778 Pindolol	Sigma-Aldrich P8688 (S)-(−)-Propranolol hydrochloride	Sigma-Aldrich SML1913 ASB14780	Sigma-Aldrich P0884 (±)-Propranolol hydrochloride
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥99% (TLC)
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility 0.1 M NaOH: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, H₂O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, acetic acid: 50 mg/mL	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL	solubility DMSO: 10 mg/mL, clear	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
color white to off-white	color -	color white to beige	color white

Still not finding the right product?

Explore all of our products under Pindolol

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Discover Bioactive Small Molecules for ADME/Tox

DISCOVER Bioactive Small Molecules for Neuroscience

Effects of a beta-blocker on the cardiovascular response to MDMA (Ecstasy).

C M Hysek et al.

Emergency medicine journal : EMJ, 27(8), 586-589 (2010-04-10)

MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') produces tachycardia and hypertension and is rarely associated with cardiovascular and cerebrovascular complications. In clinical practice, beta-blockers are often withheld in patients with stimulant intoxication because they may increase hypertension and coronary artery vasospasm due to loss

The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2

Williams E T, et al.

Drug Metabolism and Disposition (2008)

Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts

Pelkonen L, et al.

European Journal of Pharmaceutical Sciences, 162-168 (2017)

View All Related Papers

Global Trade Item Number

SKU	GTIN
P0778-250MG	04061832083520
P0778-1G	04061825982601

Questions

Reviews

No rating value