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A2987

Atractylenolide III

≥98% (HPLC)

Synonym(s):

8β-Hydroxyasterolide, Codonolactone

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10 mg
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$535.00
$401.25

About This Item

Empirical Formula (Hill Notation):
C15H20O3
CAS Number:
73030-71-4
Molecular Weight:
248.32
NACRES:
NA.25
PubChem Substance ID:
329770808
UNSPSC Code:
12352200
MDL number:
MFCD00238543

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biological source

Atractylodes macrocephala Koidz.

Quality Level

100

assay

≥98% (HPLC)

form

powder or crystals

color

white to off-white

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

CC1=C2C[C@H]3C(=C)CCC[C@]3(C)C[C@]2(O)OC1=O

InChI

1S/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1

InChI key

FBMORZZOJSDNRQ-GLQYFDAESA-N

General description

Atractylenolide III is a biologically active sesquiterpene compound, extracted from the roots of Atractylodes macrocephala Koidzumi.[1][2]

Application

Atractylenolide III, a sesquiterpenoid, is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide III may be used and studied as an inhibitor of aromatases and inducer of apoptosis. Atractylenolide III may be used to study its sonic hedgehog pathway dependent mechanism of action as an inducer of chondrogenic differentiation. Atractylenolide III may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma.
Atractylenolide III has been used to examine its effects on the energy metabolism in the skeletal muscles of mouse.[1]

Biochem/physiol Actions

Atractylenolide III has been shown to possess anti-inflammatory effects and also offers gastroprotection.[1][2][3] It also shows acaricidal properties and hence has the potential to be used as an agent for the control of dust mites.[4] Atractylenolide III is capable of regulating the secretion and expression of Interleukin-6, thereby mediating the immune response caused by mast cells.[5]
Atractylenolide III possesses anti-inflammatory and anticancer properties.

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This Item
PHL80359PHL82480PHL82479
Atractylenolide III ≥98% (HPLC)

Sigma-Aldrich

A2987

Atractylenolide III

Atractylenolide III phyproof® Reference Substance

PHL80359

Atractylenolide III

Atractylenolide II phyproof® Reference Substance

PHL82480

Atractylenolide II

Atractylenolide I phyproof® Reference Substance

PHL82479

Atractylenolide I

form

powder or crystals

form

-

form

-

form

-

biological source

Atractylodes macrocephala Koidz.

biological source

-

biological source

-

biological source

-

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

assay

≥95.0% (HPLC)

assay

≥98.0% (HPLC)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

food and beverages

application(s)

food and beverages

application(s)

food and beverages

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT1483
MKCP3932
MKCM8573
MKCG5880
MKCD3590

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Kun-Teng Wang et al.
The Journal of pharmacy and pharmacology, 62(3), 381-388 (2010-05-22)
The rhizome of Atractylodes ovata De Candolle is popularly used in traditional Chinese medicine to treat gastrointestinal diseases. However, the major gastroprotective compounds of A. ovata have not been identified. This study reports on the principal gastro- protective component of
Hyun-Kyung Kim et al.
Journal of agricultural and food chemistry, 55(15), 6027-6031 (2007-06-28)
The acaricidal activity of materials derived from rhizome of Atractylodes ovata (Atractylodes macrocephala) toward adult Dermatophagoides farinae and Dermatophagoides pteronyssinus was examined using fabric-circle residual contact and vapor-phase toxicity bioassays. Results were compared with those of the currently used acaricides:
Xican Li et al.
Biological & pharmaceutical bulletin, 35(8), 1328-1335 (2012-08-07)
Molecules that enhance chondrogenic differentiation in mesenchymal stem cells (MSCs) were identified and isolated using an in vitro Gli reporter gene assay in MSCs incorporating a Sonic Hedgehog (Shh) target. Atractylenolide III, which promoted Gli1-mediated transcriptional activity, was isolated from
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Global Trade Item Number

SKUGTIN
A2987-50MG04061833046852
A2987-10MG04061833046845

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