Cephalexin hydrate (C4895) is soluble in DMSO and methanol.
C4895
Cephalexin hydrate
first-generation cephalosporin antibiotic
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 g | Please contact Customer Service for Availability | $210.00 | |
| 10 g | Please contact Customer Service for Availability | $368.00 | |
| 25 g | Please contact Customer Service for Availability | $711.00 |
About This Item
Empirical Formula (Hill Notation):
C16H17N3O4S · xH2O
CAS Number:
Molecular Weight:
347.39 (anhydrous basis)
PubChem Substance ID:
UNSPSC Code:
51282503
NACRES:
NA.85
EC Number:
239-773-6
MDL number:
Beilstein/REAXYS Number:
965503
Quality Level
form
powder
pKa
7.3, 5.2
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
S1C2N(C(=C(C1)C)C(=O)O)C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3.O
InChI
1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15?;/m1./s1
InChI key
AVGYWQBCYZHHPN-FNOHQHCYSA-N
General description
Chemical structure: β-lactam
Application
Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.
Other Notes
Storage of this product should be in airtight containers and protected from light.
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This Item | |||
|---|---|---|---|
| mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder or crystals | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| pKa 5.2 | pKa - | pKa - | pKa - |
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Alexander Perniss et al.
Scientific reports, 8(1), 5681-5681 (2018-04-11)
Several species of the Gram-negative genus Bordetella are the cause of respiratory infections in mammals and birds, including whooping cough (pertussis) in humans. Very recently, a novel atypical species, Bordetella pseudohinzii, was isolated from laboratory mice. These mice presented no
William T Gray et al.
Cell, 177(6), 1632-1648 (2019-06-01)
The scaling of organelles with cell size is thought to be exclusive to eukaryotes. Here, we demonstrate that similar scaling relationships hold for the bacterial nucleoid. Despite the absence of a nuclear membrane, nucleoid size strongly correlates with cell size
Hiroshi Kodaira et al.
The Journal of pharmacology and experimental therapeutics, 339(3), 935-944 (2011-09-22)
This study investigated the impact of the active efflux mediated by P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) on the predictability of the unbound brain concentration (C(u,brain)) by the concentration in the cerebrospinal fluid
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C4895-10G | 04061835512287 |
| C4895-5G | 04061835543427 |
| C4895-25G | 04061835543410 |
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What solvent should I use to dissolve item C4895, Cephalexin hydrate?
1 answer-
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how many are in the bottles
1 answer-
This product is supplied in powder form and is currently available in 5 gram, 10 gram, and 25 gram pack sizes. This product is intended for research use only and is unsuitable for human or veterinary use.
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