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C8145

Cefsulodin sodium salt hydrate

third-generation cephalosporin antibiotic

Synonym(s):

7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C22H19N4NaO8S2 · xH2O
CAS Number:
52152-93-9
Molecular Weight:
554.53 (anhydrous basis)
NACRES:
NA.85
PubChem Substance ID:
24278340
UNSPSC Code:
51284140
EC Number:
257-692-4
MDL number:
MFCD07793338

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InChI key

REACMANCWHKJSM-DWBVFMGKSA-M

InChI

1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

SMILES string

[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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This Item
C5020C5793C7912
Cefsulodin sodium salt hydrate third-generation cephalosporin antibiotic

Sigma-Aldrich

C8145

Cefsulodin sodium salt hydrate

Cefazolin sodium salt 89.1-110.1%

Sigma-Aldrich

C5020

Cefazolin sodium salt

Ceftriaxone disodium salt hemi(heptahydrate) third-generation cephalosporin antibiotic

Sigma-Aldrich

C5793

Ceftriaxone disodium salt hemi(heptahydrate)

Cefotaxime sodium salt potency: 916-964 μg per mg

Sigma-Aldrich

C7912

Cefotaxime sodium salt

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder or crystals

form

powder

form

powder or crystals

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Chemical structure: β-lactam

Application

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier[1].
Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000534471
0000534425
0000534424
0000534471
0000534425

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T H Tsai et al.
Journal of chromatography. A, 914(1-2), 83-87 (2001-05-19)
A microdialysis method followed by a microbore liquid chromatographic ultraviolet detection procedure has been performed for the assay of unbound cefsulodin in rat blood. A microdialysis probe was inserted into the jugular vein for blood sampling. This method involves an
B Nerli et al.
Biochemistry and molecular biology international, 40(4), 823-831 (1996-11-01)
The binding to human serum albumin of three cephalosporins of pharmacological interest: cefoperazone, ceftriaxone and cefsulodin was studied by ultrafiltration and differential scanning calorimetry methods. The identification of the binding sites in albumin was also performed using probes for the
Friederike Hilbert et al.
International journal of food microbiology, 84(1), 111-115 (2003-06-05)
Yersinia enterocolitica is an important foodborne pathogen, but isolation of virulent Yersinia from food sources is still time consuming and requires skills. In this article, we describe a rapid urease screening on cefsulodin-irgasan-novobiocin (CIN) agar plates with an agar overlay
G Foster et al.
Journal of applied microbiology, 95(1), 155-159 (2003-06-17)
To compare the sensitivity of two pre-enrichment broth media prior to immunomagnetic separation for the isolation of Escherichia coli O157 from cattle faeces. One-gram portions of 721 cattle faeces collected from 43 farms were pre-enriched in buffered peptone water containing
Paul G Higgins et al.
Water research, 140, 261-267 (2018-05-04)
The elimination of potentially pathogenic bacteria in wastewater treatment plants (WWTPs) attracts much attention in public health. Reports on the occurrence of the emerging hospital pathogen Acinetobacter baumannii in wastewaters do not include a continuous monitoring at all WWTP stages.
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