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C8145

Cefsulodin sodium salt hydrate

third-generation cephalosporin antibiotic

Synonym(s):

7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt

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100 mg
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$114.00
250 mg
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$182.00
1 g
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$520.00

About This Item

Empirical Formula (Hill Notation):
C22H19N4NaO8S2 · xH2O
CAS Number:
52152-93-9
Molecular Weight:
554.53 (anhydrous basis)
NACRES:
NA.85
PubChem Substance ID:
24278340
UNSPSC Code:
51284140
EC Number:
257-692-4
MDL number:
MFCD07793338

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Quality Level

200

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1

InChI

1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

InChI key

REACMANCWHKJSM-DWBVFMGKSA-M

General description

Chemical structure: β-lactam

Application

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier[1].
Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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This Item
C5020C5793C7912
Cefsulodin sodium salt hydrate third-generation cephalosporin antibiotic

Sigma-Aldrich

C8145

Cefsulodin sodium salt hydrate

Cefazolin sodium salt 89.1-110.1%

Sigma-Aldrich

C5020

Cefazolin sodium salt

Ceftriaxone disodium salt hemi(heptahydrate) third-generation cephalosporin antibiotic

Sigma-Aldrich

C5793

Ceftriaxone disodium salt hemi(heptahydrate)

Cefotaxime sodium salt potency: 916-964 μg per mg

Sigma-Aldrich

C7912

Cefotaxime sodium salt

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder or crystals

form

powder

form

powder or crystals

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000560158
0000534471
0000534425
0000534424
0000534471

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T H Tsai et al.
Journal of chromatography. A, 914(1-2), 83-87 (2001-05-19)
A microdialysis method followed by a microbore liquid chromatographic ultraviolet detection procedure has been performed for the assay of unbound cefsulodin in rat blood. A microdialysis probe was inserted into the jugular vein for blood sampling. This method involves an
Danièle Joseleau-Petit et al.
Journal of bacteriology, 189(18), 6512-6520 (2007-06-26)
Growing bacterial L forms are reputed to lack peptidoglycan, although cell division is normally inseparable from septal peptidoglycan synthesis. To explore which cell division functions L forms use, we established a protocol for quantitatively converting a culture of a wild-type
Bianca A Amézquita-López et al.
PloS one, 7(12), e51565-e51565 (2012-12-20)
Shiga toxin-producing Escherichia coli (STEC) are zoonotic enteric pathogens associated with human gastroenteritis worldwide. Cattle and small ruminants are important animal reservoirs of STEC. The present study investigated animal reservoirs for STEC in small rural farms in the Culiacan Valley
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Global Trade Item Number

SKUGTIN
C8145-250MG04061833521861
C8145-1G04061833521854
C8145-100MG04061838820433

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