C8145

Cefsulodin sodium salt hydrate

Name: Cefsulodin sodium salt hydrate
Brand: SIGMA
Price: 69 EUR

third-generation cephalosporin antibiotic

Synonym(e):

7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt

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100 MG

€ 69,00

250 MG

€ 110,00

1 G

€ 344,00

€ 69,00

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₂H₁₉N₄NaO₈S₂ · xH₂O

CAS-Nummer:

52152-93-9

Molekulargewicht:

554.53 (anhydrous basis)

NACRES:

NA.85

PubChem Substance ID:

24278340

UNSPSC Code:

51284140

EC Number:

257-692-4

MDL number:

MFCD07793338

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InChI key

REACMANCWHKJSM-DWBVFMGKSA-M

InChI

1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

SMILES string

[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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Dieser Artikel	C5020	C5793	C7912
Sigma-Aldrich C8145 Cefsulodin sodium salt hydrate	Sigma-Aldrich C5020 Cefazolin sodium salt	Sigma-Aldrich C5793 Ceftriaxone disodium salt hemi(heptahydrate)	Sigma-Aldrich C7912 Cefotaxime sodium salt
mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes
antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder or crystals	form powder	form powder or crystals	form powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

General description

Chemical structure: β-lactam

Application

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier[1].

Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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The detection of Shiga toxin-producing Escherichia coli in diagnostic bovine faecal samples using vancomycin-cefixime-cefsulodin blood agar and PCR.

M A Hornitzky et al.

FEMS microbiology letters, 198(1), 17-22 (2001-04-28)

The prevalence of complex Shiga toxin-producing Escherichia coli (STEC), i.e. STEC containing accessory virulence factors intimin (eaeA) and/or enterohaemorrhagic E. coli haemolysin (ehxA) and their serotypes were determined in diagnostic bovine faecal samples processed during a 3 months period. The

Unstable Escherichia coli L forms revisited: growth requires peptidoglycan synthesis.

Danièle Joseleau-Petit et al.

Journal of bacteriology, 189(18), 6512-6520 (2007-06-26)

Growing bacterial L forms are reputed to lack peptidoglycan, although cell division is normally inseparable from septal peptidoglycan synthesis. To explore which cell division functions L forms use, we established a protocol for quantitatively converting a culture of a wild-type

Radiation induced effects on cephalosporins: an ESR study.

J P Basly et al.

International journal of radiation biology, 75(2), 259-263 (1999-03-11)

This paper reports experimental data on the ESR identification of four irradiated cephalosporins (cefpodoxime, cefsulodin, cefixime and ceftizoxime). Equations to describe the ESR curves versus the dose and storage time were developed using mathematical procedures. Limits of detection (LOD) and

Sub-inhibitory cefsulodin sensitization of E. coli to β-lactams is mediated by PBP1b inhibition.

Sujoy K Sarkar et al.

PloS one, 7(11), e48598-e48598 (2012-11-10)

The combination of antibiotics is one of the strategies to combat drug-resistant bacteria, though only a handful of such combinations are in use, such as the β-lactam combinations. In the present study, the efficacy of a specific sub-inhibitory concentration of

Detection of hemolysin variants of Shiga toxin-producing Escherichia coli by PCR and culture on vancomycin-cefixime-cefsulodin blood agar.

A Lehmacher et al.

Applied and environmental microbiology, 64(7), 2449-2453 (1998-07-02)

The presence of a hemolysin-encoding gene, elyA or hlyA, from Shiga toxin-producing Escherichia coli (STEC) was detected by PCR in each of 95 strains tested. PCR products of elyA from human STEC isolates of serovars frequently detected in Germany, such

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Cefsulodin sodium salt hydrate