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C8261

Sodium chenodeoxycholate

≥97%

Synonym(s):

3α,7α-Dihydroxy-5β-cholanic acid, 5β-Cholanic acid-3α,7α-diol, Chenodeoxycholic acid sodium salt, Chenodesoxycholic acid, Chenodiol

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About This Item

Empirical Formula (Hill Notation):
C24H39NaO4
CAS Number:
2646-38-0
Molecular Weight:
414.55
NACRES:
NA.25
PubChem Substance ID:
24893037
UNSPSC Code:
12161900
MDL number:
MFCD00065452

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InChI

1S/C24H40O4.Na.H/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26;;/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28);;/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-;;/m1../s1

SMILES string

[Na].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])CC[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(O)=O

InChI key

WANBNZVOEKGHSS-VQNKLXGESA-N

description

anionic

assay

≥97%

form

powder

mol wt

414.55 g/mol

technique(s)

protein purification: suitable

Quality Level

200

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Show Differences

1 of 4

This Item
30970C644527029
Sodium chenodeoxycholate ≥97%

Sigma-Aldrich

C8261

Sodium chenodeoxycholate

Sodium deoxycholate BioXtra, ≥98.0% (dry matter, NT)

Sigma-Aldrich

30970

Sodium deoxycholate

Sodium cholate hydrate BioXtra, ≥99%

Sigma-Aldrich

C6445

Sodium cholate hydrate

Sodium cholate hydrate ≥97.0% (dried material, NT)

Sigma-Aldrich

27029

Sodium cholate hydrate

assay

≥97%

assay

≥98.0% (dry matter, NT)

assay

≥99%

assay

≥97.0% (dried material, NT)

form

powder

form

powder

form

powder

form

powder

technique(s)

protein purification: suitable

technique(s)

DNA purification: suitable, RNA purification: suitable, electrophoresis: suitable

technique(s)

-

technique(s)

-

mol wt

414.55 g/mol

mol wt

micellar avg mol wt 1200-5000

mol wt

micellar avg mol wt 900-1300

mol wt

micellar avg mol wt 900-1300

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

description

anionic

description

anionic

description

anionic

description

anionic

General description

Sodium chenodeoxycholate is a bile salt, which has been shown to accelerate colonic transit and improve bowel function. [1]

Application

Sodium chenodeoxycholate has been used in a study to assess DNA repair response in the bacterium Escherichia coli. [2] It has also been used in a study to investigate the physical and chemical factors influencing germination of Clostridium difficile spores. [3]

Biochem/physiol Actions

Bile Salt

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000517528
0000517528
0000457370
0000457369
0000457370

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L J Wheeldon et al.
Journal of applied microbiology, 105(6), 2223-2230 (2009-01-06)
To investigate the influence of chemical and physical factors on the rate and extent of germination of Clostridium difficile spores. Germination of C. difficile spores following exposure to chemical and physical germinants was measured by loss of either heat or
R L Kandell et al.
Nutrition and cancer, 16(3-4), 227-238 (1991-01-01)
Two bile salts, sodium chenodeoxycholate and sodium deoxycholate, induced a DNA repair response in the bacterium Escherichia coli. Similarly, a bile acid and a bile salt, chenodeoxycholic acid and sodium deoxycholate, induced DNA repair (indicated by unscheduled DNA synthesis) in
V Vanhoorne et al.
Orphanet journal of rare diseases, 14(1), 186-186 (2019-08-03)
Pharmaceutical compounding of orphan active ingredients can offer cost-effective treatment to patients when no other drug product is available for a rare disease or during periods of drug product shortages. Additionally, it allows customized therapy for patients with rare diseases.
Tina Kauss et al.
Journal of pharmaceutical sciences, 108(8), 2805-2813 (2019-03-18)
Current pediatric antibiotic therapies often use oral and parenteral routes of administration. Neither are suitable for treating very sick neonates who cannot take oral medication and may be several hours away from hospital in developing countries. Here, we report on
Sarinya Tawthep et al.
Journal of bioscience and bioengineering, 124(5), 514-522 (2017-07-29)
Understanding the dynamics of secondary bile acid (SBA) formation in the gut by SBA-producing bacteria is important for host health, as SBAs have been shown to affect host pathophysiology and gut microbiota composition. However, our knowledge of SBA producers is
View All Related Papers

Articles

Probiotics and Human Health

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

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