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F4381

Furosemide

≥98% (HPLC), powder, NKCC symporter inhibitor

Synonym(s):

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

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Pack SizeSKUAvailabilityPrice
1 g
Please contact Customer Service for Availability
$88.30
5 g
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$394.00
10 g
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$488.00
$414.80
25 g
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$789.00

About This Item

Empirical Formula (Hill Notation):
C12H11ClN2O5S
CAS Number:
Molecular Weight:
330.74
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-203-6
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:

$88.30


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Product Name

Furosemide,

biological source

synthetic (organic)

Quality Level

assay

≥98% (HPLC)

form

powder

mp

220 °C (dec.) (lit.)

solubility

acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow

originator

Sanofi Aventis

storage temp.

room temp

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

General description

Furosemide is a an ototoxic high-ceiling diuretic.

Application

Furosemide has been used:
  • to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
  • to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
  • as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Biochem/physiol Actions

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
Inhibits ion co-transport in the kidney.
Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
PHR1057BP5471287008
Furosemide British Pharmacopoeia (BP) Reference Standard

BP547

Furosemide

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

solid

form

-

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

room temp

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

-

solubility

acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow

solubility

-

solubility

-

solubility

-

originator

Sanofi Aventis

originator

-

originator

-

originator

-


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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Related Content

Product Information Sheet


Diuretics
Side Effects of Drugs Annual, 28, 233-243 (2005)
Topiramate is more effective than acetazolamide at lowering intracranial pressure
Scotton W J, et al.
Cephalalgia, 0333102418776455-0333102418776455 (2018)
Causes of acquired hearing loss
Eggermont J J
Hearing Loss: Causes, Prevention, and Treatment (2017)



Global Trade Item Number

SKUGTIN
F4381-5G04061832574486
F4381-10G04061833617687
F4381-25G04061832574479
F4381-1G04061833617694

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