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Merck

O7389

Olprinone hydrochloride

≥98% (HPLC), solid

Synonym(s):

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H10N4O · HCl
CAS Number:
119615-63-3
Molecular Weight:
286.72
NACRES:
NA.77
PubChem Substance ID:
24724566
UNSPSC Code:
41106305
MDL number:
MFCD01749474

Key Documents

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InChI

1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

SMILES string

Cl[H].CC1=C(C=C(C#N)C(=O)N1)c2ccc3nccn3c2

InChI key

PWTBMBAQRAOAFF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

beige

solubility

DMSO: ≤4 mg/mL, H2O: 6.8 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Selective phosphodiesterase 3 (PDE3) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
056K47151
056K4715

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Mayumi Tachikawa et al.
Masui. The Japanese journal of anesthesiology, 61(6), 566-573 (2012-07-04)
Beta blockers are frequently used to reduce cardiac oxygen demand in off-pump coronary artery bypass grafting (OPCAB). However, significant bradycardia or negative inotropic effects are seen on occasion. We hypothesized that combined use of landiolol (L), an ultra short-acting beta
Katsushi Kinouchi et al.
General thoracic and cardiovascular surgery, 60(2), 73-81 (2012-02-14)
The benefit of terminal blood cardioplegia (TWBCP) is insufficient after prolonged ischemia associated with inevitable oxidant-mediated injury by this modality alone. We tested the effects of TWBCP supplemented with high-dose olprinone, which is a phosphodiesterase III inhibitor, a clinically available
Jing Zhou et al.
European journal of anaesthesiology, 28(7), 519-524 (2011-04-16)
Phosphodiesterase 3 (PDE3) inhibitors and sevoflurane are both known to have bronchodilator properties and the combination of these two agents may be synergistic. We tested this hypothesis in a model of airway hyperresponsiveness using ovalbumin-sensitised guinea pigs. Animals were randomised
Hiroo Yamanaka et al.
Journal of cardiovascular pharmacology, 57(5), 579-583 (2011-02-18)
Neuropsychological dysfunction with cardiopulmonary bypass (CPB) may be facilitated by inadequate cerebral oxygen balance during CPB. Olprinone, a phosphodiesterase III inhibitor, augments cerebral blood flow by a direct vasodilator effect on cerebral arteries. We conducted the present randomized study in
Martin Kertys et al.
Biomedical chromatography : BMC, 33(10), e4620-e4620 (2019-06-20)
A simple, highly sensitive and rapid method for quantification of olprinone (phosphodiesterase 3 inhibitor) in rabbit plasma using liquid chromatography-tandem mass spectrometry with electrospray was developed. An aliquot of 50 μL of plasma sample was cleaned up and extracted using Ostro™
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