Key Documents

View All Documentation

Bacitracin

Name: Bacitracin
Brand: SIGMA
Price: 105 USD
Availability: InStock

from Bacillus licheniformis, ≥65 IU/mg

Synonym(s):

Altracin, Bacitracin A

Select a Size

Change View

Pack Size	SKU	Availability	Price
5 g		Available to ship TODAYfromMILWAUKEE	$105.00
25 g		Available to ship TODAYfromMILWAUKEE	$385.00

About This Item

Empirical Formula (Hill Notation):

C₆₆H₁₀₃N₁₇O₁₆S

CAS Number:

1405-87-4

Molecular Weight:

1422.69

NACRES:

NA.85

PubChem Substance ID:

57646949

UNSPSC Code:

51282002

EC Number:

215-786-2

MDL number:

MFCD00062640

$105.00

Available to ship TODAYDetails

Request a Bulk Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

Bacillus licheniformis

Quality Level

200

form

powder

specific activity

≥65 IU/mg

color

white to pale buff

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[H]N1[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(N)C(C)CC)[C@@H](C)CC)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](Cc4ccccc4)C1=O

InChI

1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1

InChI key

CLKOFPXJLQSYAH-RNHDWVCBSA-N

Description

General description

Chemical structure: peptide

Application

Bacitracin is used to study disruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is also used to study the biosynthesis of sterols and squalene.
Bacitracin has been used:

as a protease inhibitor[1]
as a control antibiotic[2]
for the calibration in size exclusion chromatography[3]

Biochem/physiol Actions

Bacitracin has been shown to decrease vancomycin-resistant Enterococcus faecium population in intestine.[4]

Bacitracin is a peptide antibiotic.
Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

Packaging

5G, 25 G

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	B0125	B5150	PHR1590
Sigma-Aldrich 11702 Bacitracin	Sigma-Aldrich B0125 Bacitracin	Sigma-Aldrich B5150 Bacitracin zinc salt	Supelco PHR1590 Bacitracin
mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes	mode of action -
antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 300
form powder	form powder	form powder	form -
biological source Bacillus licheniformis	biological source Bacillus licheniformis	biological source Bacillus licheniformis	biological source -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -10 to -25°C

Still not finding the right product?

Explore all of our products under Bacitracin

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Inhibition of Cell Wall Biosynthesis by Antibiotics

β-lactam antibacterials inhibit transpeptidase enzymes, preventing peptidoglycan assembly in both Gram-positive and Gram-negative bacteria.

Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter.

Anthony W Kingston et al.

Molecular microbiology, 93(1), 37-49 (2014-05-09)

Heptaprenyl diphosphate (C35 -PP) is an isoprenoid intermediate in the synthesis of both menaquinone and the sesquarterpenoids. We demonstrate that inactivation of ytpB, encoding a C35 -PP utilizing enzyme required for sesquarterpenoid synthesis, leads to an increased sensitivity to bacitracin

Oral Bacitracin: A Consideration for Suppression of Intestinal Vancomycin-Resistant Enterococci (VRE) and for VRE Bacteremia From an Apparent Gastrointestinal Tract Source.

Truc T Tran et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(11), 1726-1728 (2015-02-24)

Monotreme lactation protein is highly expressed in monotreme milk and provides antimicrobial protection.

Ashwantha Kumar Enjapoori et al.

Genome biology and evolution, 6(10), 2754-2773 (2014-09-24)

Monotremes (platypus and echidna) are the descendants of the oldest ancestor of all extant mammals distinguished from other mammals by mode of reproduction. Monotremes lay eggs following a short gestation period and after an even briefer incubation period, altricial hatchlings

View All Related Papers

Global Trade Item Number

SKU	GTIN
213438-100ML	04061838125613
11702-5G	04061838704788
11702-25G	04061835540969

Questions

Reviews

No rating value