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M5060

E-4031

≥98% (HPLC), lyophilized powder

Synonym(s):

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

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0.1 mg
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$290.00
0.5 mg
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$838.00
$712.30
1 mg
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$1,470.00

About This Item

Empirical Formula (Hill Notation):
C21H27N3O3S · 2HCl
CAS Number:
113559-13-0
Molecular Weight:
474.44
NACRES:
NA.77
PubChem Substance ID:
329818000
UNSPSC Code:
12352207
MDL number:
MFCD01754739
Assay:
≥98% (HPLC)
Form:
lyophilized powder

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Quality Segment

100

assay

≥98% (HPLC)

form

lyophilized powder

storage condition

desiccated

technique(s)

cell culture | embryo: suitable

color

white

solubility

H2O: soluble

storage temp.

−20°C

SMILES string

Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1

InChI

1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H

InChI key

ZQBNWMFBOSOOLX-UHFFFAOYSA-N

Application

E-4031 has been used as:
  • human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
  • IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
  • IKr blocker in rat ventricular myocytes

Biochem/physiol Actions

E-4031 selectively blocks hERG K+ channels.
E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
324470SML2353SML2738
E-4031 ≥98% (HPLC), lyophilized powder

Sigma-Aldrich

M5060

E-4031

E-4031 A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC50 = 10 nM).

Sigma-Aldrich

324470

E-4031

GPR39-C3 ≥98% (HPLC)

Sigma-Aldrich

SML2353

GPR39-C3

SM1-71 ≥98% (HPLC)

Sigma-Aldrich

SML2738

SM1-71

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

solubility

H2O: soluble

solubility

DMSO: 50 mg/mL, water: 50 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

form

lyophilized powder

form

solid

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

technique(s)

cell culture | embryo: suitable

technique(s)

-

technique(s)

-

technique(s)

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000562959
0000528258
0000562959
0000528258
0000282859

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Global Trade Item Number

SKUGTIN
M5060-.1MG04061834059493
M5060-1MG04061834059516
M5060-.5MG04061834059509

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