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C160

CGP-42112A

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

Synonym(s):

Nα-Nicotinoyl-Tyr-(Nα-Cbz-Arg)-Lys-His-Pro-Ile

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1 mg

Available to ship TODAYfromMILWAUKEE

$302.00
$256.70
5 mg

Available to ship TODAYfromMILWAUKEE

$1,080.00

About This Item

Empirical Formula (Hill Notation):
C52H69N13O11
CAS Number:
127060-75-7
Molecular Weight:
1052.18
NACRES:
NA.77
PubChem Substance ID:
24892424
UNSPSC Code:
12352200
MDL number:
MFCD00133611
Beilstein/REAXYS Number:
8184948
Assay:
≥95%
Form:
solid
Quality level:
200

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Product Name

CGP-42112A, ≥95%, synthetic, solid

biological source

synthetic

Quality Level

200

assay

≥95%

form

solid

color

white

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

Gene Information

human ... AGTR2(186)
rat ... AGTR2(11609)

Application

CGP-42112A has been used:
  • in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
  • to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
  • as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

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This Item
S3672492042SML2988
CGP-42112A ≥95%, synthetic, solid

Sigma-Aldrich

C160

CGP-42112A

[Sar9, Met(O2)11]-Substance P ≥95% (HPLC)

Sigma-Aldrich

S3672

[Sar9, Met(O2)11]-Substance P

Nrf2 Activator III, TAT-14 Peptide The Nrf2 Activator III, TAT-14 Peptide modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.

Sigma-Aldrich

492042

Nrf2 Activator III, TAT-14 Peptide

Tat-NR2B9c trifluoroacetate ≥95% (HPLC)

Sigma-Aldrich

SML2988

Tat-NR2B9c trifluoroacetate

assay

≥95%

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

solid

form

-

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white

color

-

color

white

color

white to off-white

biological source

synthetic

biological source

-

biological source

-

biological source

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000511932
0000511932
0000484342
0000492066
0000492066

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Anu Vaajanen et al.
Investigative ophthalmology & visual science, 49(6), 2557-2562 (2008-01-29)
In the present study the effects of exogenous angiotensin II and its breakdown metabolite angiotensin (1-7) on the intraocular pressure (IOP) and on aqueous humor dynamics in normotensive rabbit eye were evaluated. Male New Zealand White rabbits with normal IOP
C Sumners et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7567-7571 (1991-09-01)
Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2 types of AII receptors to investigate the expression of functional receptor subtypes in astrocyte cultures and neuron cultures from 1-day-old
Nancy J Hong et al.
Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)
NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via
View All Related Papers

Global Trade Item Number

SKUGTIN
C160-1MG04061826152515
C160-5MG04061833467770

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