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P7754

5α-Pregnane-3,20-dione (allo)

progesterone metabolite

Synonym(s):

5α-Dihydroprogesterone, Allopregnane-3,20-dione

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Pack SizeSKUAvailabilityPrice
1 g

Available to ship TODAYfromMILWAUKEE

$370.00

About This Item

Empirical Formula (Hill Notation):
C21H32O2
CAS Number:
566-65-4
Molecular Weight:
316.48
NACRES:
NA.77
PubChem Substance ID:
24898872
UNSPSC Code:
51111800
EC Number:
209-297-3
MDL number:
MFCD00067132

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Quality Level

200

form

powder

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CCC(=O)C2

InChI

1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1

InChI key

XMRPGKVKISIQBV-BJMCWZGWSA-N

Biochem/physiol Actions

A high-level metabolite of progesterone in breast cancer tissue (but not normal breast tissue); promotes cell proliferation and detachment. Receptors appear only on the cell surface of MCF-7 breast cancer cells, not on nuclei where most other steroid receptors are located.

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This Item
P2016PHR2905Y0001004
5α-Pregnane-3,20-dione (allo) progesterone metabolite

Sigma-Aldrich

P7754

5α-Pregnane-3,20-dione (allo)

3α,21-Dihydroxy-5α-pregnan-20-one ≥95%

Sigma-Aldrich

P2016

3α,21-Dihydroxy-5α-pregnan-20-one

Progesterone Related Compound H pharmaceutical secondary standard, certified reference material

Supelco

PHR2905

Progesterone Related Compound H

vibrant-m

Y0001004

Dydrogesterone

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

-

form

powder

form

powder

form

-

form

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000563093
0000563093
0000559085
0000559077
0000559077

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Articles

Knoevenagel Condensation Reaction

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

Related Content

J Zhang et al.
The Journal of steroid biochemistry and molecular biology, 70(4-6), 123-131 (2000-01-06)
Progesterone inhibits intracellular transport of lysosomal cholesterol in cultured cells, and thus at least in part mimics the biochemical phenotype of Niemann-Pick type C disease (NPC) in human fibroblasts. The goal of this study was to determine whether metabolism of
George Wittemyer et al.
Hormones and behavior, 51(3), 346-354 (2007-02-27)
Non-invasive endocrine methods enable investigation of the relationship between ecological variation and ovarian activity and how this impacts on demographic processes. The underlying physiological factors driving high variation in inter-calving intervals among multi-parous African elephants offer an interesting system for
Laurence Meyer et al.
Cellular and molecular life sciences : CMLS, 67(17), 3017-3034 (2010-05-01)
Painful neuropathy is a major side-effect limiting cancer chemotherapy. Therefore, novel strategies are required to suppress the neuropathic effects of anticancer drugs without altering their chemotherapeutic effectiveness. By combining biochemical, neuroanatomical/neurochemical, electrophysiological and behavioral methods, we demonstrated that progesterone-derived neurosteroids
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Global Trade Item Number

SKUGTIN
P7754-100ML-A04061834397304
P7754-500MG04061834397335
P7754-1L-A04061837230462
P7754-500ML-A04061834397359
P7754-1G04061826757765

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