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E2895

(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide

≥98%

Synonym(s):

NOR-3

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10 mg

Available to ship TODAYfromMILWAUKEE

$374.00
$317.90

About This Item

Empirical Formula (Hill Notation):
C8H13N3O4
CAS Number:
138472-01-2
Molecular Weight:
215.21
MDL number:
MFCD00270892
UNSPSC Code:
12352200
PubChem Substance ID:
329799038
NACRES:
NA.77
Assay:
≥98%
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥98%

form

powder

solubility

DMSO: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC\C(=C/C(=N\O)C(N)=O)C(C)[N+]([O-])=O

InChI

1S/C8H13N3O4/c1-3-6(5(2)11(14)15)4-7(10-13)8(9)12/h4-5,13H,3H2,1-2H3,(H2,9,12)/b6-4+,10-7+

InChI key

MZAGXDHQGXUDDX-AGLLBGTNSA-N

Application

Cell-permeable NO donor; releases nitric oxide spontaneously in a rate-controlled manner. Half-life in solution = 30 min.

Biochem/physiol Actions

Activates intracellular guanylyl cyclase.

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This Item
E3020V108N5501
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide ≥98%

Sigma-Aldrich

E2895

(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide

(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide ≥97%

Sigma-Aldrich

E3020

(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide

(±)-Norverapamil hydrochloride ≥98% (HPLC)

Sigma-Aldrich

V108

(±)-Norverapamil hydrochloride

Nω-Nitro-L-arginine ≥98% (TLC)

Sigma-Aldrich

N5501

Nω-Nitro-L-arginine

form

powder

form

-

form

powder

form

powder

assay

≥98%

assay

≥97%

assay

≥98% (HPLC)

assay

≥98% (TLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

solubility

DMSO: 10 mg/mL, clear, colorless to faintly yellow

solubility

-

solubility

H2O: 15 mg/mL, clear

solubility

1 M HCl: 50 mg/mL, clear, colorless to faintly yellow

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7230
MKCQ3481
MKBW5539V
MKBR3847V
SLBJ4694V

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Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

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Avian schistosomes, the causative agents of human cercarial dermatitis (or swimmer's itch), die in mammals but the mechanisms responsible for parasite elimination are unknown. Here we examined the role of reactive nitrogen species, nitric oxide (NO) and peroxynitrite, in the
Y Kita et al.
European journal of pharmacology, 257(1-2), 123-130 (1994-05-12)
(+-)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide (FK409), which was isolated from microbial products, has been reported to show a vasorelaxant effect through a mechanism similar to that of the organic nitrates such as isosorbide dinitrate. In solution at pH 7.4, FK409 decomposed and released nitric
Elsa Cortés-Montero et al.
Antioxidants & redox signaling, 31(7), 503-520 (2019-05-16)
Aims: Histidine triad nucleotide-binding protein 1 (HINT1) exhibits proapoptotic and tumor-suppressive activity. HINT1 binds to transcription factors such as

Global Trade Item Number

SKUGTIN
E2895-10MG04061833261514

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