Skip to Content
MilliporeSigma
HomeProductsMolecular Biology & Functional GenomicsGene Editing & Functional Genomics

Gene Editing & Functional Genomics

The image presents a close-up view of virus particles, with a dominant golden particle in the center, characterized by its spherical shape and numerous spike proteins. The background features additional particles in golden-yellow and blue hues, all set against a blurred backdrop that accentuates the central figure and adds depth to the composition. The image captures the intricate details and diversity of virus particles, highlighting their unique structures.

Sigma-Aldrich® Advanced Genomics offers a complete suite of genome engineering and modulation products and services. Our comprehensive portfolio delivers support for every step of your research, from discovery through translational research to therapeutic impact.  

Target a single gene or screen a whole genome with fully customizable products. With tools to edit using CRISPR or ZFNs, modulate expression with CRISPRa/i or RNAi, or perform whole genome screens, you’re limited only by your scientific curiosity. And with over 350 years of technical leadership, Sigma-Aldrich® Advanced Genomics offers an unsurpassed breadth of expertise and intellectual property to help you succeed.

View All Products
CRISPR & Gene Editing

CRISPR & Gene Editing

With decades of gene editing experience and an unsurpassed portfolio of CRISPR and ZFN technology patents, Sigma-Aldrich® Advanced Genomics delivers the highest quality reagents for your entire workflow, from early-stage discovery to translational research. Whether you are looking to knockout, knock-in, knockdown, or overexpress your targets, our comprehensive suite of CRISPR gene-editing tools and services will take your research Beyond the Bench.

View Products

RNAi Single Clones

Sigma-Aldrich® Advanced Genomics RNAi Single Clones deliver powerful, long term, and stable gene silencing. As an exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC), our comprehensive offering consists of nearly 200,000 pre-cloned shRNA constructs targeting more than 22,500 human and 20,000 mouse genes.

View Products
RNAi Single Clones

Explore More Categories

The image showcases a close-up view of a multi-well plate being filled with a red liquid by an automated pipetting system. The pipettes are aligned and dispensing the liquid into the wells in unison, with a blurred background emphasizing the precision of the process. This scene is typical in laboratory settings where multiple samples are processed simultaneously for experiments or testing.
Genetic Screening

Sigma-Aldrich® Advanced Genomics offers complete solutions for your genetic screens at any scale. Whether you're targeting specific genes or performing a genome-wide screen, we offer extensive pooled and arrayed formats to meet your needs. From gene expression knockdown with CRISPRi and RNAi to overexpression with CRISPRa and ORF, we have everything you need for your target discovery research.

View Products
The image presents a close-up view of virus particles, with a dominant golden particle in the center, characterized by its spherical shape and numerous spike proteins. The background features additional particles in golden-yellow and blue hues, all set against a blurred backdrop that accentuates the central figure and adds depth to the composition. The image captures the intricate details and diversity of virus particles, highlighting their unique structures.
RNAi Libraries

Sigma-Aldrich® Advanced Genomics is the exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC). These lentivirus-based shRNA libraries deliver unparalleled coverage and are available in multiple formats that include whole-genome, individual RNAi clones/vectors, and gene family sets. Available in standard glycerol format or higher quality DNA and lentiviral formats.

View Products
Two laboratory sample vials with red caps
Custom & Predesigned RNA Oligos, siRNA Duplexes and Controls

A comprehensive portfolio of custom & predesigned RNA oligos, miRNAs, esiRNAs, and siRNA duplexes and controls, available with modification options in multiple formats comply with ISO 9001 and ISO 13485 quality systems for research and commercial applications.

View Products

Shop Products

lentiviral particles (142)

shRNA (109)

plasmids (55)

microRNA inhibitors (45)

enzymes (8)

ZFN technology (3)

Sigma-Aldrich (275)

CRISPR (73)

genome mapping (6)

genomic analysis (6)
Sort by Relevance
Showing 1-20 of 276
Change View
Showing 1-20 of 276
MISSION<SUP>®</SUP> shRNA
SHCLNG

MISSION® shRNA

Bacterial Stock

MISSION<SUP>®</SUP> shRNA
SHCLNV

MISSION® shRNA

Lentiviral Particles

MISSION<SUP>®</SUP> shRNA
SHCLND

MISSION® shRNA

Purified DNA

Cas9-GFP Protein
CAS9GFPPRO

Cas9-GFP Protein

from Streptococcus pyogenes, fused with enhanced GFP, recombinant, expressed in E. coli, 3X NLS

MISSION<SUP>®</SUP> Lentiviral Packaging Mix
SHP001

MISSION® Lentiviral Packaging Mix

Production of replication incompetent viral particles

Cas9 Protein
CAS9PROT

Cas9 Protein

from Streptococcus pyogenes, recombinant, expressed in E. coli, 1X NLS

X-tremeGENE<SUP>™</SUP> siRNA Transfection Reagent
SITRAN-RO

X-tremeGENE™ siRNA Transfection Reagent

Polymer reagent for delivering siRNA to common cell lines

MISSION<SUP>®</SUP> pLKO.1-puro Empty Vector Control Plasmid DNA
SHC001

MISSION® pLKO.1-puro Empty Vector Control Plasmid DNA

Contains no shRNA insert

MISSION<SUP>®</SUP> pLKO.1-puro Non-Target shRNA Control Plasmid DNA
SHC016

MISSION® pLKO.1-puro Non-Target shRNA Control Plasmid DNA

Targets no known genes from any species

MISSION<SUP>®</SUP> pLKO.1-puro Non-Mammalian shRNA Control Plasmid DNA
SHC002

MISSION® pLKO.1-puro Non-Mammalian shRNA Control Plasmid DNA

Targets no known mammalian genes

dCas9-3XFLAG<SUP>™</SUP>-Biotin Protein
DCAS9PROT

dCas9-3XFLAG™-Biotin Protein

from Streptococcus pyogenes with D10A and H840A mutations, recombinant, expressed in E. coli, 1X NLS

MISSION<SUP>®</SUP> pLKO.1-puro Non-Target shRNA Control Transduction Particles
SHC016V

MISSION® pLKO.1-puro Non-Target shRNA Control Transduction Particles

Targets no known genes from any species

MISSION<SUP>®</SUP> pLKO.1-puro-CMV-TurboGFP<SUP>™</SUP> Positive Control Plasmid DNA
SHC003

MISSION® pLKO.1-puro-CMV-TurboGFP™ Positive Control Plasmid DNA

Green fluorescent protein marker to monitor transduction efficiency

MISSION<SUP>®</SUP> pLKO.1-puro Non-Mammalian shRNA Control Transduction Particles
SHC002V

MISSION® pLKO.1-puro Non-Mammalian shRNA Control Transduction Particles

Targets no known mammalian genes

CMV-CAS9-2A-GFP Plasmid
CAS9GFPP

CMV-CAS9-2A-GFP Plasmid

Cas9-D10A Nickase Protein
CAS9D10APR

Cas9-D10A Nickase Protein

from Streptococcus pyogenes with D10A mutation, recombinant, expressed in E. coli, 1X NLS

eSpCas9-GFP Protein
ECAS9GFPPR

eSpCas9-GFP Protein

from Streptococcus pyogenes with mutations conferring enhanced specificity, fused with enhanced GFP, recombinant, expressed in E. coli, 3X NLS

MISSION<SUP>®</SUP> shRNA
CSTVRS

MISSION® shRNA

Custom Lentiviral Particles

Cas9 plasmid
CAS9P

Cas9 plasmid

MISSION<SUP>®</SUP> TRC2 pLKO.5-puro Empty Vector Control Plasmid DNA
SHC201

MISSION® TRC2 pLKO.5-puro Empty Vector Control Plasmid DNA

Contains no shRNA insert

You have viewed 1-20 of 276 results
Page 1 of 14
Page 1 of 14
Related Product Categories
Oligos, qPCR Probes & Peptides
Choose custom products from our comprehensive portfolio of DNA and RNA oligos, qPCR probes and peptides as we offer numerous options for manufacturing platforms, purity levels, modifications to meet a variety of research applications.
Roche Life Science Products
Roche Life Science Products provide dependable reagents for breakthrough research, ensuring high-quality, reproducible results.
NGS Library Preparation
Prepare your library for next-gen sequencing. Isolate, fragment, repair, and link nucleic acids with adapters using ligation or tagmentation methods. Essential step before DNA/RNA sequencing.
Epigenetics
Epigenetic reagents and resources for investigating RNA species, DNA methylation, chromatin modifications, and histone modifications.
PCR & Amplification
PCR reagents, kits, whole genome amplification, PCR consumables, and thermocyclers for your PCR workflow needs.
Microbiome
Comprehensive Gut Microbiome Analysis: Uncover a holistic solution encompassing sample prep, sequencing, bioinformatics, and statistics. From 16S to WGS.
Nucleic Acid Purification
DNA and RNA extraction, purification, and reaction clean-up reagents and kits.
Cloning & Expression
Explore our comprehensive offering of restriction enzymes, protein expression vectors, transfection reagents and protein expression technologies for your molecular cloning and protein expression workflow needs.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?